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DNA Sewing Machine Manipulates Delicate DNA Chains Without Breaking Them

Date:
July 10, 2008
Source:
Royal Society of Chemistry
Summary:
Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them.

Using miniaturised hooks and bobbins single DNA strands can be manoeuvred without breakage.
Credit: Image courtesy of Royal Society of Chemistry

Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The new work demonstrates a unique way to manipulate delicate DNA chains without breaking them.

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Scientists can diagnose genetic disorders such as Down's syndrome by using gene markers, or "probes", which bind to only highly similar chains of DNA. Once bound, the probe's location can be easily detected by fluorescence, and this gives information about the gene problem.

Detecting these probes is often a slow and difficult process, however, as the chains become tightly coiled. The new method presented by Kyohei Terao from Kyoto University, and colleagues from The University of Tokyo, uses micron-sized hooks controlled by lasers to catch and straighten a DNA strand with excellent precision and care.

"When a DNA molecule is manipulated and straightened by microhooks and bobbins, the gene location can be determined easily with high-spatial resolution," says Terao.

The team use optical tweezers - tightly focused laser beams - to control the Z-shaped micro hook and pick up a single DNA "thread". The hook is barbed like an arrow, so the thread can't escape. When caught on the hook, the DNA can be accurately moved around by refocusing the lasers to new positions.

But just like thread in a sewing machine, a long DNA chain can be unwieldy - so the researchers built micro "bobbins" to wind the chain around. The lasers move one bobbin around another, winding the DNA thread onto a manageable spindle.

It is "an excellent idea to fabricate unique microtools that enables us to manipulate a single giant DNA molecule", says Yoshinobu Baba, who researches biologically useful microdevices at Nagoya University, Japan. The technology will also be useful for a number of other applications including DNA sequencing and molecular electronics, he adds.


Story Source:

The above story is based on materials provided by Royal Society of Chemistry. Note: Materials may be edited for content and length.


Journal Reference:

  1. Terao et al. On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures. Lab on a Chip, 2008; DOI: 10.1039/b803753a

Cite This Page:

Royal Society of Chemistry. "DNA Sewing Machine Manipulates Delicate DNA Chains Without Breaking Them." ScienceDaily. ScienceDaily, 10 July 2008. <www.sciencedaily.com/releases/2008/07/080710110803.htm>.
Royal Society of Chemistry. (2008, July 10). DNA Sewing Machine Manipulates Delicate DNA Chains Without Breaking Them. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2008/07/080710110803.htm
Royal Society of Chemistry. "DNA Sewing Machine Manipulates Delicate DNA Chains Without Breaking Them." ScienceDaily. www.sciencedaily.com/releases/2008/07/080710110803.htm (accessed March 4, 2015).

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