Featured Research

from universities, journals, and other organizations

Searching For Shut Eye: Possible 'Sleep Gene' Identified

Date:
July 30, 2008
Source:
University of Pennsylvania School of Medicine
Summary:
While scientists and physicians know what happens if you don't get six to eight hours of shut-eye a night, investigators have long been puzzled about what controls the actual need for sleep. Researchers might have an answer, at least in fruit flies. In a recent study of fruit flies, they identified a gene that controls sleep.

In a recent study of fruit flies, scientists identified a gene that controls sleep.
Credit: iStockphoto

While scientists and physicians know what happens if you don't get six to eight hours of shut-eye a night, investigators have long been puzzled about what controls the actual need for sleep. Researchers at the University of Pennsylvania School of Medicine might have an answer, at least in fruit flies. In a recent study of fruit flies, they identified a gene that controls sleep.

"We spend -- or should spend -- a third of our lives sleeping," says Amita Sehgal, PhD, Professor of Neuroscience and an Investigator with the Howard Hughes Medical Institute (HHMI). "The idea that so much time is spent in sleep is intriguing. Also, sleep deprivation has serious health consequences and impairs cognitive function."

This study was published in the latest Science.

Fruit flies typically sleep 12 hours a day. Sehgal and her team studied 3,500 fruit flies and found mutants that survived on little to no sleep – one to two hours a day or none at all. The sleepless flies had a mutation of a gene that Sehgal and her team have named Sleepless. They believe the Sleepless gene encodes a protein that affects whether potassium ion channels in the brain stay open or closed. When the channels are open, the brain is connected and working – the fly is awake. When closed, the channel shuts down and the fly sleeps. The insomniac fruit flies had less of the Sleepless-produced protein.

The lack of sleep didn't come without consequences. The Sleepless fruit flies lived about half as long as fruit flies that did not carry the mutation. They also experience impaired coordination and restlessness in their few hours of sleep.

Sleep is regulated by two processes: circadian and homeostatic. Circadian regulation affects the timing of sleep, and the homeostatic mechanism affects the need for sleep. The Sleepless gene affects the homeostatic mechanism.

Sleep isn't just for humans – it's been observed in everything from flies to dogs to people, indicating that it's essential to life. Insufficient and poor-quality sleep is an increasing problem in industrialized nations. In the U.S. alone, about 70 million people suffer from chronic sleep problems, which reduce workplace productivity, affect quality of life and can even be lethal.

"In the long term, we hope that human equivalents of our gene will be isolated and will not only further our understanding of human sleep, but perhaps also serve as drug targets to promote sleep or treat insomnia," says Sehgal.

In addition to Sehgal, Kyunghee Koh, William J. Joiner, Mark N. Wu, Zhifeng Yue, and Corinne J. Smith, all from Penn and HHMI, were authors on the paper. The National Institutes of Health, University of Pennsylvania, and the Burroughs-Wellcome Foundation provided funding for this research.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of Pennsylvania School of Medicine. "Searching For Shut Eye: Possible 'Sleep Gene' Identified." ScienceDaily. ScienceDaily, 30 July 2008. <www.sciencedaily.com/releases/2008/07/080729160819.htm>.
University of Pennsylvania School of Medicine. (2008, July 30). Searching For Shut Eye: Possible 'Sleep Gene' Identified. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2008/07/080729160819.htm
University of Pennsylvania School of Medicine. "Searching For Shut Eye: Possible 'Sleep Gene' Identified." ScienceDaily. www.sciencedaily.com/releases/2008/07/080729160819.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins