Featured Research

from universities, journals, and other organizations

Cholesterol-lowering Drug Boosts Bone Repair

Date:
July 31, 2008
Source:
BioMed Central
Summary:
Lovastatin, a drug used to lower cholesterol and help prevent cardiovascular disease, has been shown to improve bone healing in an animal model of neurofibromatosis type 1. The research, reported today in the open access journal BMC Medicine, will be of great interest to NF1 patients and their physicians.

Lovastatin, a drug used to lower cholesterol and help prevent cardiovascular disease, has been shown to improve bone healing in an animal model of neurofibromatosis type 1 (NF1). The research, reported today in the open access journal BMC Medicine, will be of great interest to NF1 patients and their physicians.

Many NF1 patients suffer from bowing, spontaneous fractures and pseudarthrosis (incomplete healing) of the tibias (shinbones). Mateusz Kolanczyk from Stefan Mundlos' laboratory in the Max Planck Institute for Molecular Genetics, Berlin, led a team that investigated lovastatin's ability to prevent pseudarthrosis in a new animal model of human NF1 disease.

Current therapies are often futile when applied to pseudarthrosis of the tibia; in some cases, amputation is the only option. To better understand this problem, Kolanczyk and his colleagues developed this mouse model. He said, "In our model, the mice showed tibial bowing similar to that observed in NF1 patients, however since mouse legs are not subjected to the same excessive mechanical forces as humans, we also applied a bone injury model". The authors drilled a 0.5mm hole in the tibia of anaesthetised mice. As they describe, "This enables analysis of the complex process of bone repair while at the same time causing the least possible distress to the animals".

The process of bone repair was examined 7, 14 and 28 days post-injury. The authors found that the mice given the statin treatment had marked improvements in bone healing compared to the control animals. As they report, "Lovastatin appears to accelerate cortical bone repair primarily by enhancing new bone formation within the bone marrow cavity and by replacing fibro-cartilaginous tissue in the injury site with mineralised bone matrix".

Kolanczyk concludes, "Our results suggest the usefulness of lovastatin, a drug approved in 1987 for the treatment of high cholesterol, in the treatment of neurofibromatosis-related fracture healing abnormalities". The experimental model presented here constitutes a valuable tool for the preclinical testing of other candidate drugs that target similar bone problems.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mateusz Kolanczyk, Jirko Kuehnisch, Nadine Kossler, Monika Osswald, Sabine Stumpp, Boris Thurisch, Uwe Kornak and Stefan Mundlos. Modelling NF1 tibial dysplasia and its treatment with lovastatin. BMC Medicine, (in press) [link]

Cite This Page:

BioMed Central. "Cholesterol-lowering Drug Boosts Bone Repair." ScienceDaily. ScienceDaily, 31 July 2008. <www.sciencedaily.com/releases/2008/07/080730222209.htm>.
BioMed Central. (2008, July 31). Cholesterol-lowering Drug Boosts Bone Repair. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2008/07/080730222209.htm
BioMed Central. "Cholesterol-lowering Drug Boosts Bone Repair." ScienceDaily. www.sciencedaily.com/releases/2008/07/080730222209.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins