Featured Research

from universities, journals, and other organizations

Importance Of Sex-specific Testing Shown In Anxiety Study

Date:
October 18, 2008
Source:
Garvan Institute of Medical Research
Summary:
An Australian study has flagged an important truth for the medical research community. Like their human counterparts, male and female mice are not only different, their respective genetic responses can often be the reverse of what you'd expect from pharmacological results. This has important ramifications for laboratory and clinical testing.

An Australian study has flagged an important truth for the medical research community. Like their human counterparts, male and female mice are not only different, their respective genetic responses can often be the reverse of what you'd expect from pharmacological results. This has important ramifications for laboratory and clinical testing.

Related Articles


Dr Tim Karl, behavioural neuroscientist at the Garvan Institute of Medical Research, found the opposite of what he expected in female mice when he investigated the anxiety behaviours of males and females in specific mouse models.

"There's a neurotransmitter in the brain known as NPY, and we know that it buffers behavioural consequences of stress, lowering anxiety levels," explained Karl. "Pharmacological tests show that when you introduce NPY to an animal in a stressful situation, its stress levels decrease."

"Studies in the past have shown that male mice created without NPY are more anxious than normal mice, which is hardly surprising. What is surprising is that female mice without NPY, while still more anxious than normal mice, are less anxious than the males without NPY."

"Knowing that normal female mice respond in a different way to stress than normal male mice, in the same way that women respond differently to stress than men - they are at least twice as prone to anxiety disorders for example - we didn't expect what we found."

"The outcomes tell us that you have to do both genetic studies and pharmacological studies to get the whole picture and see what your gene of interest is really doing."

"You also have to look at males and females because we operate differently. Women show a better response to certain antipsychotics than men, for example."

"Using female mice in research is complicated by the females' oestrus cycle - it impacts on neuro-physiological parameters, including behaviour and perception of stress. For these reasons, and because of the additional time and cost involved in taking such variations into account, people often avoid using females in their research."

"But when a sexual difference has bearing on the physiological response under investigation, it becomes vital to look at males and females, both in animals and in humans."

These results were reported recently in the European Journal of Neuroscience.


Story Source:

The above story is based on materials provided by Garvan Institute of Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Garvan Institute of Medical Research. "Importance Of Sex-specific Testing Shown In Anxiety Study." ScienceDaily. ScienceDaily, 18 October 2008. <www.sciencedaily.com/releases/2008/10/081015100051.htm>.
Garvan Institute of Medical Research. (2008, October 18). Importance Of Sex-specific Testing Shown In Anxiety Study. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2008/10/081015100051.htm
Garvan Institute of Medical Research. "Importance Of Sex-specific Testing Shown In Anxiety Study." ScienceDaily. www.sciencedaily.com/releases/2008/10/081015100051.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Jockey Motion Tracking Reveals Racing Prowess

Jockey Motion Tracking Reveals Racing Prowess

Reuters - Innovations Video Online (Mar. 26, 2015) Using motion tracking technology, researchers from the Royal Veterinary College (RVC) are trying to establish an optimum horse riding style to train junior jockeys, as well as enhance safety, health and well-being of both racehorses and jockeys. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Botswana Talks to End Illegal Wildlife Trade

Botswana Talks to End Illegal Wildlife Trade

AFP (Mar. 25, 2015) Experts are gathering in Botswana to try to end the illegal wildlife trade that is decimating populations of elephants, rhinos and other threatened species. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Elephants Help Keep 18-Wheeler From Toppling Over

Elephants Help Keep 18-Wheeler From Toppling Over

Newsy (Mar. 25, 2015) The Natchitoches Parish Sheriff&apos;s Office discovered two elephants keeping a tractor-trailer that had gotten stuck in some mud upright on a highway. Video provided by Newsy
Powered by NewsLook.com
Baby 'pet' Orangutan Rescued from Chicken Cage Takes First Steps

Baby 'pet' Orangutan Rescued from Chicken Cage Takes First Steps

Reuters - Light News Video Online (Mar. 25, 2015) Buti, a baby orangutan who was left malnourished in a chicken cage before his rescue, takes his first steps after months of painful physical therapy. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins