Featured Research

from universities, journals, and other organizations

New Research Finds Markers For Esophageal Cancer Before It Develops

Date:
November 10, 2008
Source:
Lifespan
Summary:
Researchers have identified genetic proteins, also known as biomarkers, capable of distinguishing changes at the microscopic level that can signal a precancerous condition in the esophagus. These markers may help identify patients who are likely to progress to esophageal cancer.

Rhode Island Hospital researchers have identified genetic proteins, also known as biomarkers, capable of distinguishing changes at the microscopic level that can signal a precancerous condition in the esophagus. These markers may help identify patients who are likely to progress to esophageal cancer. This first of its kind study is published in the journal Clinical Cancer Research.

Related Articles


Barrett's esophagus (BE) is a common precancerous condition of the lower esophagus. Patients with BE need to be screened by endoscopy and biopsied at frequent intervals in order to detect premalignant changes at the microscopic level. The presence of BE increases the risk of developing esophageal adenocarcinoma (EAC), the most common form of esophageal cancer.

Lead author Murray Resnick, MD, comments, "Identification of biomarkers capable of distinguishing the grade of Barrett's esophagus-associated dysplasia, as well as identifying patients who are most likely to progress to cancer, would be extremely valuable tools for both surgical pathologists and gastroentorologists."

The progression of BE to EAC occurs in a series of steps from low-grade dysplasia (earliest morphological sign of precancer) to high-grade dysplasia (HGD). Approximately half of all patients who experience HGD will progress to EAC. Several genetic abnormalities have been identified that support the transition from HGD to EAC. Currently morphological analysis of esophageal biopsies by light microscopy is considered the gold standard for identifying HGD, thereby guiding a treatment plan for these patients. Distinguishing between LGD and HGD, however, can be challenging for pathologists to detect using light microscopy alone.

Resnick says, "As pathologists, our primary goal was to identify candidate biomarker proteins suitable for the generation of specific antibodies that could detect these proteins using immunohistochemical diagnostic techniques that are readily available in all pathology departments."

With that in mind, researchers at Rhode Island Hospital's Molecular Pathology Core Facility and the Division of Gastroenterology, along with researchers at the Oregon Health and Science University, and Massachusetts General Hospital, set out to identify biomarkers that could distinguish between low-grade and high-grade dysplasia.

Using state-of-the-art molecular techniques, including laser capture microdissection followed by gene expression analysis, the researchers identified a number of potential biomarkers. Resnick concludes, "Using this process, it is the first study of its kind to differentiate genes expressed in HGD versus other grades of BE-associated dysplasia. While additional studies on a larger series of cases is required, this study provides promise for our future ability to identify which patients have the potential to develop esophageal adenocarcinoma and to provide an appropriate treatment plan."

Other researchers involved in the study include: Edmond Sabo, Patricia Meitner, Rosemarie Tavares, and Steven Moss of Rhode Island Hospital; Christopher Corless of Oregon Health and Science University, Portland, Oregon; and Gregory Lauwers of Massachusetts General Hospital.

The study was funded by a COBRE Center for Cancer Research Development grant from the National Institutes of Health.


Story Source:

The above story is based on materials provided by Lifespan. Note: Materials may be edited for content and length.


Cite This Page:

Lifespan. "New Research Finds Markers For Esophageal Cancer Before It Develops." ScienceDaily. ScienceDaily, 10 November 2008. <www.sciencedaily.com/releases/2008/11/081103130929.htm>.
Lifespan. (2008, November 10). New Research Finds Markers For Esophageal Cancer Before It Develops. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2008/11/081103130929.htm
Lifespan. "New Research Finds Markers For Esophageal Cancer Before It Develops." ScienceDaily. www.sciencedaily.com/releases/2008/11/081103130929.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins