Featured Research

from universities, journals, and other organizations

'Femtomolar Optical Tweezers' May Enable Sensitive Blood Tests

Date:
November 17, 2008
Source:
National Institute of Standards and Technology (NIST)
Summary:
Cutting-edge "tweezers" are so sensitive that they can feel the tell-tale tug of tiny concentrations of pathogens in blood samples, yet don't ever need to be sterilized--or even held--as they are ephemeral and weightless.

Basic scheme of an optical tweezer-based sensor of biological particles. A microsphere covered with a specific antigen (such as a virus or other infectious agent) is trapped and pulled away from a surface containing the corresponding antibodies. The minimum amount of force applied to the tweezers to break the bonds can provide information on the concentration of antibodies on the surface.
Credit: NIST

Cutting-edge “tweezers” are so sensitive that they can feel the tell-tale tug of tiny concentrations of pathogens in blood samples, yet don’t ever need to be sterilized—or even held—as they are ephemeral and weightless.

The National Institute of Standards and Technology (NIST) has licensed a patented “optical tweezers” technique for detecting and measuring very small concentrations of a biological substance—such as a virus on a surface. NIST has issued a non-exclusive license for the technology to Haemonetics, a global health care company that provides blood management technologies for hospitals and blood and plasma collection agencies.

Optical tweezers are actually tightly focused laser beams. They can trap certain objects, such as latex microspheres or biological cells, and move them around in water. This occurs because the lasers' electric fields interact with electric charges on the objects.

To detect disease-causing agents, researchers can coat a microsphere with antibody particles and then touch it to a surface containing infectious particles (antigens). The antigens then stick to the antibodies on the sphere, reminiscent of Velcro, in which loops on one strip combine with hooks on the other. By determining how much laser power is required to pull the microsphere away from the surface, one can then calculate the amount of force needed to break off the antibodies from the antigens and thus count the number of individual antigens that were bound to the sphere. This in turn can detect and count biological antigens at extraordinarily low “femtomolar” concentrations—roughly equivalent to one antigen particle per quadrillion (1,000,000,000,000,000) water molecules.

Following up on earlier work in optical tweezers in the industrial and academic research communities in the 1970s, the licensed technology was patented in 1997 (patent #5,620,857), as a result of research conducted under the NIST BioSensor Consortium. The inventors are Howard Weetall (since retired), Kristian Helmerson, and guest researcher Rani Kishore.


Story Source:

The above story is based on materials provided by National Institute of Standards and Technology (NIST). Note: Materials may be edited for content and length.


Cite This Page:

National Institute of Standards and Technology (NIST). "'Femtomolar Optical Tweezers' May Enable Sensitive Blood Tests." ScienceDaily. ScienceDaily, 17 November 2008. <www.sciencedaily.com/releases/2008/11/081113162901.htm>.
National Institute of Standards and Technology (NIST). (2008, November 17). 'Femtomolar Optical Tweezers' May Enable Sensitive Blood Tests. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2008/11/081113162901.htm
National Institute of Standards and Technology (NIST). "'Femtomolar Optical Tweezers' May Enable Sensitive Blood Tests." ScienceDaily. www.sciencedaily.com/releases/2008/11/081113162901.htm (accessed October 23, 2014).

Share This



More Matter & Energy News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Chameleon Camouflage to Give Tanks Cloaking Capabilities

Chameleon Camouflage to Give Tanks Cloaking Capabilities

Reuters - Innovations Video Online (Oct. 22, 2014) — Inspired by the way a chameleon changes its colour to disguise itself; scientists in Poland want to replace traditional camouflage paint with thousands of electrochromic plates that will continuously change colour to blend with its surroundings. The first PL-01 concept tank prototype will be tested within a few years, with scientists predicting that a similar technology could even be woven into the fabric of a soldiers' clothing making them virtually invisible to the naked eye. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Jet Sales Lift Boeing Profit 18 Pct.

Jet Sales Lift Boeing Profit 18 Pct.

Reuters - Business Video Online (Oct. 22, 2014) — Strong jet demand has pushed Boeing to raise its profit forecast for the third time, but analysts were disappointed by its small cash flow. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Internet of Things Aims to Smarten Your Life

Internet of Things Aims to Smarten Your Life

AP (Oct. 22, 2014) — As more and more Bluetooth-enabled devices are reaching consumers, developers are busy connecting them together as part of the Internet of Things. (Oct. 22) Video provided by AP
Powered by NewsLook.com
What Is Magic Leap, And Why Is It Worth $500M?

What Is Magic Leap, And Why Is It Worth $500M?

Newsy (Oct. 22, 2014) — Magic Leap isn't publicizing much more than a description of its product, but it’s been enough for Google and others to invest more than $500M. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins