Featured Research

from universities, journals, and other organizations

Insights Into Adaptive Ability Of Cells May Help Explain How Cancer Eludes Body's Natural Defense

Date:
December 1, 2008
Source:
Stowers Institute for Medical Research
Summary:
Scientists have shed light on the ability of cells to adapt to disruptions to their basic division machineries -- a finding that may help explain how cancer cells elude the body's natural defense mechanisms or chemotherapy treatment.

The Stowers Institute's Rong Li Lab has published findings that shed light on the ability of cells to adapt to disruptions to their basic division machineries – findings that may help explain how cancer cells elude the body's natural defense mechanisms or chemotherapy treatment.

Working with yeast cells, the team disabled a motor protein, type II myosin — which normally powers cell division — and observed the cellular response. As predicted, blocking division initially resulted in severe growth and cytokinesis defects. But after several selection passages, some cells were able to solve the problems. Unexpectedly, these cells ended up with more than the normal number of chromosomes. The abnormal chromosome numbers led to changes in the patterns of gene expression, which correlated with the cells' ability to evolve new ways to complete division and resume growth.

"The ability of cellular systems to evolve is linked to their component and network complexity, which allows the cell to develop 'workarounds' to salvage normal functions, even in times of crisis," said Giulia Rancati, Ph.D., Postdoctoral Research Associate and co-equal lead author on the paper. "Surprisingly, the adaptation was accomplished not by changes in DNA sequences but largely by modifying the number of chromosomes in the cell (known as aneuploidy), which were passed on to future generations."

The work was published in the November 26 issue of Cell.

"Another process that contributed to the successful adaptation involved polyploidization, in which yeast cells multiplied their entire set of chromosomes," said Norman Pavelka, Ph.D., Postdoctoral Research Associate and co-equal lead author on the paper. "Aneuploidy and polyploidy are hallmarks of cancer, and these findings suggest that they may contribute directly to the ability of cancer cells to evolve, allowing them to multiply, even as the body's natural mechanisms for cellular regulation or chemotherapeutic drug treatment work to limit their growth."

The work establishes an exciting new path for the Rong Li Lab.

"These findings validated our view that evolvability is a trackable and important subject for study," said Rong Li, Ph.D., Investigator and senior author on the paper. "We are now working to determine whether there are many distinct mechanisms of evolvability correlating with varying types and degrees of cellular disruptions. Additionally, we would like to explore the possibility of predicting the likely evolutionary paths and outcomes based on the architecture of molecular networks present in the cell; and in extending our research into mammalian cell systems to directly study the role of aneuploidy in the evolution of cancer."

Additional contributing authors from the Stowers Institute include Brian Fleharty, Microarray Research Technician II; Aaron Noll, Molecular Biology Programmer Analyst III; Rhonda Trimble, Histology Specialist III; Kendra Walton, Molecular Biology Research Technician III; Anoja Perera, Molecular Biology Lab Manager III; Karen Staehling-Hampton, Ph.D., Managing Director of Molecular Biology; and Chris Seidel, Ph.D., Managing Director of Microarray.


Story Source:

The above story is based on materials provided by Stowers Institute for Medical Research. Note: Materials may be edited for content and length.


Cite This Page:

Stowers Institute for Medical Research. "Insights Into Adaptive Ability Of Cells May Help Explain How Cancer Eludes Body's Natural Defense." ScienceDaily. ScienceDaily, 1 December 2008. <www.sciencedaily.com/releases/2008/11/081126133432.htm>.
Stowers Institute for Medical Research. (2008, December 1). Insights Into Adaptive Ability Of Cells May Help Explain How Cancer Eludes Body's Natural Defense. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2008/11/081126133432.htm
Stowers Institute for Medical Research. "Insights Into Adaptive Ability Of Cells May Help Explain How Cancer Eludes Body's Natural Defense." ScienceDaily. www.sciencedaily.com/releases/2008/11/081126133432.htm (accessed August 1, 2014).

Share This




More Plants & Animals News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pyrenees Orphan Bear Cub Gets Brand New Home

Pyrenees Orphan Bear Cub Gets Brand New Home

AFP (Aug. 1, 2014) — The discovery of a bear cub in the Pyrenees mountains made headlines in April 2014. Despire several attempts to find the animal's mother, the cub remained alone. Now, the Pyrenees Conservation Foundation has constructed an enclosure. Duration: 00:31 Video provided by AFP
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) — Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) — Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) — Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins