Featured Research

from universities, journals, and other organizations

Bariatric Surgery May Resolve Liver Disease

Date:
December 2, 2008
Source:
American Gastroenterological Association
Summary:
A recent study reports bariatric surgery results in improvement of histopathological features of nonalcoholic fatty liver disease (NAFLD). Complications of NAFLD, including steatosis, steatohepatitis and fibrosis appeared to improve or completely resolve in a majority of patients after bariatric surgery-induced weight loss, according to new results.

Obesity is a growing epidemic in the U.S. with a significant increase in prevalence from 15 percent to 32.9 percent from 1980 to 2004. Nonalcoholic fatty liver disease (NAFLD) is an emerging problem related to the obesity epidemic, becoming one of the most common causes of liver disease in the nation.

Bariatric surgery has become a popular and effective method for rapid and permanent significant weight loss in morbidly obese individuals. A recent study reports bariatric surgery results in improvement of histopathological features of NAFLD. Complications of NAFLD, including steatosis, steatohepatitis and fibrosis appeared to improve or completely resolve in a majority of patients after bariatric surgery-induced weight loss, according to results of a study published in Clinical Gastroenterology and Hepatology, an official journal of the American Gastroenterological Association (AGA) Institute.

"Even today, the effect of weight loss after bariatric surgery on the liver, particularly NAFLD, remains unclear. There is a lack of well-defined trials exploring this relationship," said Gagan K. Sood, MD, of the University of Texas Medical Branch and lead author of the study. "Our team assessed and quantified this effect and found encouraging news: a majority of patients experience complete resolution of NAFLD after bariatric surgery, and the risk of progression of inflammatory changes and fibrosis seems to be minimal."

For this meta-analysis, 15 studies were selected for final data extraction. The mean age of the participants at the time of weight loss surgery ranged from 35.6 to 49 years. Mean BMI at the time of weight loss surgery ranged from 43.9 to 56 kg/m2 and the mean BMI at follow-up liver biopsies ranged from 28.6 to 39kg/m2. Percentage reduction in mean BMI values ranged from 19.11 to 41.76.

The pooled proportion of patients with improvement or resolution in steatosis was 91.6 percent, steatohepatitis was 81.3 percent, fibrosis was 65.5 percent and complete resolution of NASH was 69.5 percent.

Generalizability of these results may require confirmation from multi-center, large scale, well designed trials. Future studies need to be done using uniform histopathological criteria for liver biopsy specimens.

NAFLD encompasses a range of conditions involving the liver that affect people who drink little or no alcohol. The spectrum of NAFLD ranges from hepatic steatosis (fat accumulation in the liver cells) to the more severe non-alcoholic steatohepatitis (NASH) and fibrosis that can progress to cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Prevalence of NAFLD is estimated to be around 70 percent in obese individuals and 85 percent to 95 percent in patients with morbid obesity. The prevalence of NASH is as high as 18.5 percent in obese individuals and 33 percent in those who are morbidly obese. The pathophysiologic mechanisms of NAFLD have not been clearly elucidated as yet, but obesity and insulin resistance are considered to be the main causative factors.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Cite This Page:

American Gastroenterological Association. "Bariatric Surgery May Resolve Liver Disease." ScienceDaily. ScienceDaily, 2 December 2008. <www.sciencedaily.com/releases/2008/12/081201081907.htm>.
American Gastroenterological Association. (2008, December 2). Bariatric Surgery May Resolve Liver Disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/12/081201081907.htm
American Gastroenterological Association. "Bariatric Surgery May Resolve Liver Disease." ScienceDaily. www.sciencedaily.com/releases/2008/12/081201081907.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins