Featured Research

from universities, journals, and other organizations

Scientists Prove Endothelial Cells Give Rise To Blood Stem Cells

Date:
December 6, 2008
Source:
University of California - Los Angeles
Summary:
Stem cell researchers have proven definitively that blood stem cells are made during mid-gestational embryonic development by endothelial cells, the cells that line the inside of blood vessels.

Stem cell researchers at UCLA have proven definitively that blood stem cells are made during mid-gestational embryonic development by endothelial cells, the cells that line the inside of blood vessels.

While the anatomic location in the embryo where blood stem cells originate has been well documented, the cell type from which they spring was less understood. The UCLA finding, published in the Dec. 4, 2008 issue of the journal Cell Stem Cell, puts to rest a long-standing controversy over whether blood stem cells were created, or born, in the endothelium or originated from another cell type in a nearby location.

Researchers from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA used a cell fate tracing technique to identify the source of blood stem cells. They genetically marked endothelial cells to discover what other cells they gave rise to and where those cells migrated to in the body.

"We genetically traced the endothelial cells to find out what they became over time," said Luisa Iruela-Arispe, senior author of the paper, a professor of molecular, cell and developmental biology and director of the Cancer Cell Biology Program Area at UCLA's Jonsson Comprehensive Cancer Center. "In that way, we were able to understand that, within the embryo, endothelial cells were responsible for the generation of blood stem cells. They make blood, they aren't just the pipes that carry it."

The finding ultimately could lead to new therapies for certain blood disorders and cancers, said Ann Zovein, the first author of the study and a California Institute for Regenerative Medicine-Broad Stem Cell Research Center Training Grant postdoctoral fellow in Iruela-Arispe's lab.

Blood stem cells currently cannot be grown outside of the body without losing their "stemness," meaning they then differentiate into the different cells that make up blood, including red blood cells, white blood cells and platelets. If blood stem cells can be gown outside the body from endothelial cells and only self-renew, or make more of their own kind, researchers may one day be able to reprogram blood vessel cells to produce blood stem cells to replace the bone marrow in transplants or the mutated blood cells that result in diseases like leukemia.

"We found that endothelial cells are capable of making blood stem cells within embryonic areas that prevent differentiation into other lineages," Zovein said. "In trying to understand how blood stem cells arise from the endothelium, we may learn enough to be able to grow pure, designer blood stem cells outside the human body."

For example, researchers may some day be able to take a blood vessel from a patient and grow blood stem cells specific to that patient, which could be used for bone marrow transplantation. Since the blood stem cells originated from the patient, there would be no need to find a matching donor to provide the marrow. The cells also could be used to replace diseased cells that result in cancer, providing a new way to treat malignancies such as leukemia.

The creation of blood stem cells by endothelial cells occurs at a specific time in embryonic development and researchers want to know what takes place biologically during that period, what specific cell signaling pathways are sending the messages to make blood stem cells. Iruela-Arispe and her team hope to mimic the embryonic environment in the lab to create blood cells that don't differentiate.

"Next we need to understand what signaling mechanisms are at work that allow endothelial cells to make blood stem cells," Iruela-Arispe said. "We need to find out how we can program the endothelial cells to make blood stem cells, what's important in the embryonic blood vessel wall that allows for this phenomenon and whether we can reprogram adult blood vessels to do the same thing."

While this study was done in mouse models, Iruela-Arispe and her team will be working with human endothelial cells to confirm their work and further uncover the cell signaling mechanisms in play.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "Scientists Prove Endothelial Cells Give Rise To Blood Stem Cells." ScienceDaily. ScienceDaily, 6 December 2008. <www.sciencedaily.com/releases/2008/12/081203131039.htm>.
University of California - Los Angeles. (2008, December 6). Scientists Prove Endothelial Cells Give Rise To Blood Stem Cells. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2008/12/081203131039.htm
University of California - Los Angeles. "Scientists Prove Endothelial Cells Give Rise To Blood Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2008/12/081203131039.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins