Featured Research

from universities, journals, and other organizations

New Way To More Rapidly Generate Bone Tissue Developed

Date:
December 19, 2008
Source:
Columbia University Medical Center
Summary:
Using stem cell lines not typically combined, researchers have designed a new way to 'grow' bone and other tissues. The work takes a new approach: rarely have mesenchymal and hematopoietic cells been delivered in combination for the healing of defects and the treatment of diseases -- partially due to the separate research communities in which these two cell groups are studied.

Using stem cell lines not typically combined, researchers at Columbia University Medical Center have designed a new way to "grow" bone and other tissues.

Related Articles


The inability to foster angiogenesis – a physiological process involving the growth of new blood vessels from pre-existing vessels – has been a major roadblock in tissue regeneration. Previous approaches have included the use of angiogenic growth factors and the fabrication of artificial blood vessels. However, there are problems associated with these approaches. Among these problems: artificially fabricated blood vessels do not readily branch out and network with host blood vessels, and blood vessels induced by angiogenic growth factors tend to be immature and "leaky."

To overcome these obstacles, a team of Columbia researchers has co-transplanted hematopoietic and mesenchymal stem/progenitor cells to promote the regeneration of vascularized tissues. What they found was that the tissue regenerated in bone more rapidly than when either type of stem cell was used alone.

The work by Jeremy Mao, DDS, Ph.D., published December 15 in PLoS ONE, takes a new approach: rarely have mesenchymal and hematopoietic cells been delivered in combination for the healing of defects and the treatment of diseases – partially due to the separate research communities in which these two cell groups are studied.

"Dr. Mao's research in tissue engineering represents the fruits of interdisciplinary science. His work has relevance for oral health care, as well as many other health care disciplines," said Dr. Ira Lamster, Dean of the Columbia University College of Dental Medicine.

Dr. Mao and colleagues demonstrated that when human mesenchymal stem/progenitor cells were seeded in micropores of 3D calcium phosphate scaffolds, followed by infusion of gel-suspended CD34+ hematopoietic cells, greater vascularization was seen in mice than when mesenchymal cells were used alone.

Furthermore, Dr. Mao's team found that the number of vessels and the diameter of the vessels produced by the co-transplantation of hematopoietic and mesenchymal to create vascularized tissue were dramatically increased when combined with Vascular Endothelial Growth Factor or VEGF.

"The work has potential beyond bones and may have implications for the growth of muscle, nerve and organs," Dr. Mao said. "The synergistic action of mesenchymal cells and hematopoietic cells provide an alternative approach for regrowing a host of vascular tissues."

Dr. Mao's colleagues and co-authors on the paper are Eduardo K. Moioli, Ph.D., Mo Chen, Ph.D., Helaman P. Erickson, DDS, and, all of the Columbia University College of Dental Medicine Tissue Engineering and Regenerative Medicine Laboratory; Paul A. Clark, Ph.D., at the University of Wisconsin at Madison Hospital. Department of Neurological Surgery; and James Dennis, Ph.D. and Stan Gerson, M.D., Ph.D. both of Case Western Reserve University Case Comprehensive Cancer Center and Dept. of Orthopaedics.


Story Source:

The above story is based on materials provided by Columbia University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Moioli et al. Synergistic Actions of Hematopoietic and Mesenchymal Stem/Progenitor Cells in Vascularizing Bioengineered Tissues. PLoS ONE, 2008; 3 (12): e3922 DOI: 10.1371/journal.pone.0003922

Cite This Page:

Columbia University Medical Center. "New Way To More Rapidly Generate Bone Tissue Developed." ScienceDaily. ScienceDaily, 19 December 2008. <www.sciencedaily.com/releases/2008/12/081215140936.htm>.
Columbia University Medical Center. (2008, December 19). New Way To More Rapidly Generate Bone Tissue Developed. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2008/12/081215140936.htm
Columbia University Medical Center. "New Way To More Rapidly Generate Bone Tissue Developed." ScienceDaily. www.sciencedaily.com/releases/2008/12/081215140936.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins