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Killer Peptide May Offer New Therapy Against Influenza A Virus

Date:
December 27, 2008
Source:
American Society for Microbiology
Summary:
In a new study researchers identified what appears to be the first antibody-derived peptide that inhibits the activities of harmful microbes such as influenza A virus and HIV-1.

In a new study researchers identified what appears to be the first antibody-derived peptide that inhibits the activities of harmful microbes such as influenza A virus and HIV-1.

Influenza A viruses continue to result in hospitalization and death, especially among infants, the elderly, and immunocompromised patients worlwide. The emergence of avian influenza A virus and its ability to transfer to humans has brought about new concerns of a pandemic outbreak. Although vaccination can be an effective strategy for preventing influenza, researchers are also placing great emphasis on the discovery and development of antiviral drugs.

A killer decapeptide (KP) represents the internal image of a yeast (Pichia anomala) killer toxin that has an antimicrobial effect against pathogenic organisms. In the study activities of a KP against influenza A virus were evaluated and results showed that KP demonstrated a significant inhibitory effect on the replication of two strains of influenza A virus. Further, mice infected with influenza virus A were inoculated with KP once a day for ten days resulting in an improved survival rate of 40% and significantly decreased viral levels in their lungs.

"Overall, KP appears to be the first anti-idiotypic antibody-derived peptide that displays inhibitory activity and that has a potential therapeutic effect against pathogenic microorganisms, HIV-1, and influenza A virus by different mechanisms of action," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Conti, W. Magliani, S. Conti, L. Nencioni, R. Sgarbanti, A.T. Palamara, L. Polonelli. Therapeutic activity of an anti-idiotypic antibody-derived killer peptide against influenza A virus experimental infection. Antimicrobial Agents and Chemotherapy, 52. 12: 4331-4337

Cite This Page:

American Society for Microbiology. "Killer Peptide May Offer New Therapy Against Influenza A Virus." ScienceDaily. ScienceDaily, 27 December 2008. <www.sciencedaily.com/releases/2008/12/081219093652.htm>.
American Society for Microbiology. (2008, December 27). Killer Peptide May Offer New Therapy Against Influenza A Virus. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2008/12/081219093652.htm
American Society for Microbiology. "Killer Peptide May Offer New Therapy Against Influenza A Virus." ScienceDaily. www.sciencedaily.com/releases/2008/12/081219093652.htm (accessed September 2, 2014).

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