Featured Research

from universities, journals, and other organizations

Killer Peptide May Offer New Therapy Against Influenza A Virus

Date:
December 27, 2008
Source:
American Society for Microbiology
Summary:
In a new study researchers identified what appears to be the first antibody-derived peptide that inhibits the activities of harmful microbes such as influenza A virus and HIV-1.

In a new study researchers identified what appears to be the first antibody-derived peptide that inhibits the activities of harmful microbes such as influenza A virus and HIV-1.

Influenza A viruses continue to result in hospitalization and death, especially among infants, the elderly, and immunocompromised patients worlwide. The emergence of avian influenza A virus and its ability to transfer to humans has brought about new concerns of a pandemic outbreak. Although vaccination can be an effective strategy for preventing influenza, researchers are also placing great emphasis on the discovery and development of antiviral drugs.

A killer decapeptide (KP) represents the internal image of a yeast (Pichia anomala) killer toxin that has an antimicrobial effect against pathogenic organisms. In the study activities of a KP against influenza A virus were evaluated and results showed that KP demonstrated a significant inhibitory effect on the replication of two strains of influenza A virus. Further, mice infected with influenza virus A were inoculated with KP once a day for ten days resulting in an improved survival rate of 40% and significantly decreased viral levels in their lungs.

"Overall, KP appears to be the first anti-idiotypic antibody-derived peptide that displays inhibitory activity and that has a potential therapeutic effect against pathogenic microorganisms, HIV-1, and influenza A virus by different mechanisms of action," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Conti, W. Magliani, S. Conti, L. Nencioni, R. Sgarbanti, A.T. Palamara, L. Polonelli. Therapeutic activity of an anti-idiotypic antibody-derived killer peptide against influenza A virus experimental infection. Antimicrobial Agents and Chemotherapy, 52. 12: 4331-4337

Cite This Page:

American Society for Microbiology. "Killer Peptide May Offer New Therapy Against Influenza A Virus." ScienceDaily. ScienceDaily, 27 December 2008. <www.sciencedaily.com/releases/2008/12/081219093652.htm>.
American Society for Microbiology. (2008, December 27). Killer Peptide May Offer New Therapy Against Influenza A Virus. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/12/081219093652.htm
American Society for Microbiology. "Killer Peptide May Offer New Therapy Against Influenza A Virus." ScienceDaily. www.sciencedaily.com/releases/2008/12/081219093652.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins