Featured Research

from universities, journals, and other organizations

Structure Of Key Ebola Protein Discovered

Date:
January 13, 2009
Source:
Iowa State University
Summary:
Scientists are a step closer to finding a way to counter the Ebola virus. They have recently solved the structure from a key part of the Ebola protein known as VP35.

Research led by Iowa State University scientists has them a step closer to finding a way to counter the Ebola virus.

A team led by Gaya Amarasinghe, an assistant professor in biochemistry, biophysics and molecular biology, has recently solved the structure from a key part of the Ebola protein known as VP35.

VP35 interferes with the natural resistance of host cells against viral infections.

"Usually when viruses infect cells, the host immune system can fight to eventually clear the virus. But with Ebola infections, the ability of the host to mount a defense against the invading virus is lost," said Amarasinghe.

This is because the VP35 protein interferes with the host's innate immune pathways that form the first line of defense against pathogens, he said.

In their research directed toward understanding host-viral interactions, Amarasinghe and his research team used a combination of X-ray crystallography and nucleic magnetic resonance spectroscopy to solve the structure using non-infectious protein samples.

A report describing the findings is published this week in the journal Proceedings of the National Academy of Sciences of the United States of America.

Now that the structure from a key part of VP35 is available, this information can be used as a template for anti-viral drug discovery.

"The next step is to use this structure to identify and design drugs that potentially bind with VP35," he said.

If a drug that inhibits VP35 function can be discovered, then the Ebola virus could potentially be neutralized.

"Without functional VP35, the Ebola virus cannot replicate so it is noninfectious," said Amarasinghe.

The Ebola virus can cause hemorrhagic fever that is usually fatal. According to the Center for Disease Control and Prevention, outbreaks have caused more than 1,000 deaths, mostly in Central Africa, since it was first recognized in 1976.

Amarasinghe co-authored this study with Daisy Leung, assistant scientist; Nathaniel Ginder, graduate student; Bruce Fulton, associate scientist; and Richard Honzatko, professor; all from Iowa State's biochemistry, biophysics and molecular biology department, together with Christopher Basler, associate professor from Mount Sinai School of Medicine in New York City and Jay Nix from the Berkeley National Laboratory in Berkeley, Calif.

Work in the Amarasinghe laboratory was funded in part by the Roy J. Carver Charitable Trust.


Story Source:

The above story is based on materials provided by Iowa State University. Note: Materials may be edited for content and length.


Cite This Page:

Iowa State University. "Structure Of Key Ebola Protein Discovered." ScienceDaily. ScienceDaily, 13 January 2009. <www.sciencedaily.com/releases/2009/01/090112201208.htm>.
Iowa State University. (2009, January 13). Structure Of Key Ebola Protein Discovered. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/01/090112201208.htm
Iowa State University. "Structure Of Key Ebola Protein Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/01/090112201208.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins