Featured Research

from universities, journals, and other organizations

Key Developmental Mechanisms Of The Amygdala Identified

Date:
January 17, 2009
Source:
Children's National Medical Center
Summary:
For the first time, scientists have successfully identified a key developmental program for the amygdala -- the part of the limbic system that impacts how the brain creates emotional memories and responses. This knowledge could help scientists to better understand autism and similar disorders in which altered function of this region is known to occur.

For the first time, scientists at Children's National Medical Center have successfully identified a key developmental program for the amygdala—the part of the limbic system that impacts how the brain creates emotional memories and responses.

Related Articles


This knowledge could help scientists to better understand autism and similar disorders in which altered function of this region is known to occur.

The findings, published in the February edition of Nature Neuroscience, identify a group (otherwise known as a pool) of precursor cells of neurons that are earmarked specifically for the amygdala and comprise part of a unique system of growth and development for this portion of the brain.

"Despite its central role in normal brain function and behavior, little has been known about how neuronal cell diversity is generated during development of the amygdala," said senior author Joshua Corbin, PhD, of the Center for Neuroscience Research at Children's National. "It was thought that development of this region occurred similarly to other brain structures like the cerebral cortex, but our findings indicate that a specific precursor pool exists that is pre-assigned exclusively to the limbic system. It is a breakthrough to our understanding of this little studied region of the brain."

Using studies of embryonic mice, Corbin and his team located two specific pools of precursor cells marked by the transcription factor Dbx1 that migrate from both the ventral pallium and the preoptic area—a previously undiscovered pool of migratory cells—to create the requisite mix of excitatory and inhibitory neurons that ultimately comprise the amygdala. Remarkably, the preoptic area precursor cells are exclusive contributors to the development of the limbic system, and no other portion of the brain.

"Altered function of the amygdala is a hallmark characteristic of disorders such as autism," said Dr. Corbin. "A more clear understanding of the normal development of this important brain structure provides a roadmap to understand the consequences of altered brain development in neurodevelopmental disorders."

The study was funded by the National Institute of Drug Abuse at the National Institutes of Health.


Story Source:

The above story is based on materials provided by Children's National Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hirata et al. Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. Nature Neuroscience, 2009; DOI: 10.1038/nn.2241

Cite This Page:

Children's National Medical Center. "Key Developmental Mechanisms Of The Amygdala Identified." ScienceDaily. ScienceDaily, 17 January 2009. <www.sciencedaily.com/releases/2009/01/090113074144.htm>.
Children's National Medical Center. (2009, January 17). Key Developmental Mechanisms Of The Amygdala Identified. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/01/090113074144.htm
Children's National Medical Center. "Key Developmental Mechanisms Of The Amygdala Identified." ScienceDaily. www.sciencedaily.com/releases/2009/01/090113074144.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins