Featured Research

from universities, journals, and other organizations

Immune System: Decoding The Language Of Memory Cells

Date:
January 23, 2009
Source:
University of Missouri-Columbia
Summary:
When an infection attacks, the body's immune system sounds the alert, kills the invading germs and remembers the pathogen to protect against contracting the same type of infection again. Exactly how immunological memory develops is a mystery just beginning to be unveiled in an article in the journal Science.

When an infection attacks, the body's immune system sounds the alert, kills the invading germs and remembers the pathogen to protect against contracting the same type of infection again. Exactly how immunological memory develops is a mystery just beginning to be unveiled by Emma Teixeiro, PhD, in an article published in the journal Science.

The key finding is that a distinct program generates the memory cells that protect an individual against re-infection. This current work uncovers some of the language that is necessary to start this program, said Teixeiro, assistant professor of molecular microbiology, immunology and surgery at the University of Missouri School of Medicine.

Teixeiro cites vaccination as the most practical example of how to generate cells that remember infections. With a single shot, the body is infected with a small dose of a pathogen, so the next time the body is exposed, it immediately recognizes the invader and fights it off, preventing disease.

"When the human body is infected, T cells recognize the pathogen with a specific receptor and kill the infection," Teixeiro said. "But once the infection has been cleared, a small number of cells survive. These are the memory T cells."

Teixeiro's lab used a mouse model to test how communication inside a T cell would affect a body's ability to fight infection. Two groups of mice – some with normal T cells and others with a mutation in their pathogen receptor – were infected with listeria monocytogenes, a bacterium often associated with food-borne illness in humans. Both groups of mice fought off the infection equally well, but those with the cell mutation were not able to generate memory T cells to protect against future infection due to a disruption in certain signals within the cell.

"A person with this cell mutation would not develop memory T cells. If we knew what was necessary to generate these memory cells, we would not need to worry about fighting the same infection over and over again," Teixeiro said, noting a direction for continued research. "We are currently figuring out which signals are important for memory generation and protection. This is important for improving vaccines and tumor immunotherapies."


Story Source:

The above story is based on materials provided by University of Missouri-Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Different T Cell Receptor Signals Determine CD8 Memory Versus Effector Development. Science, January 23, 2009

Cite This Page:

University of Missouri-Columbia. "Immune System: Decoding The Language Of Memory Cells." ScienceDaily. ScienceDaily, 23 January 2009. <www.sciencedaily.com/releases/2009/01/090122141150.htm>.
University of Missouri-Columbia. (2009, January 23). Immune System: Decoding The Language Of Memory Cells. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/01/090122141150.htm
University of Missouri-Columbia. "Immune System: Decoding The Language Of Memory Cells." ScienceDaily. www.sciencedaily.com/releases/2009/01/090122141150.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins