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Potential Atherosclerosis Drug Exhibits No Harmful Side-effects In Liver

Date:
February 23, 2009
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have developed and tested a synthetic atherosclerosis drug that can reduce the build-up of dangerous blood vessel plaques without producing the side-effect of fatty liver disease. The encouraging results of this study in mice could lead to a new type of drug to treat or even prevent atherosclerosis.

Researchers have developed and tested a synthetic atherosclerosis drug that can reduce the build-up of dangerous blood vessel plaques without producing the side-effect of fatty liver disease (which leads to its own set of problems like diabetes). The encouraging results of this study in mice could lead to a new type of drug to treat or even prevent atherosclerosis.

Targets of this drug, called DMHCA, are proteins called the Liver X Receptors (LXR). These proteins control a body's cholesterol levels by limiting the absorption of dietary cholesterol and by increasing the conversion of cholesterol into bile acids. Unfortunately, most LXR ligands also control fatty acid production, so therapeutic compounds that activate LXR also raise the levels of other fats, particularly in the liver.

DHMCA, though, had negligible effects of fat production in laboratory tests, so Dagmar Kratky and colleagues tested it in mice genetically engineered to be atherosclerotic. They found that compared to another experimental LXR drug (T0901317), DMHCA could significantly reduce the size of arterial lesions in the mice (45-48%) without increasing fat content in the liver or blood.

Together, these results, appearing in the February Journal of Lipid Research, show much therapeutic promise.


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kratzer et al. Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. The Journal of Lipid Research, 2008; 50 (2): 312 DOI: 10.1194/jlr.M800376-JLR200

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Potential Atherosclerosis Drug Exhibits No Harmful Side-effects In Liver." ScienceDaily. ScienceDaily, 23 February 2009. <www.sciencedaily.com/releases/2009/02/090213115024.htm>.
American Society for Biochemistry and Molecular Biology. (2009, February 23). Potential Atherosclerosis Drug Exhibits No Harmful Side-effects In Liver. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/02/090213115024.htm
American Society for Biochemistry and Molecular Biology. "Potential Atherosclerosis Drug Exhibits No Harmful Side-effects In Liver." ScienceDaily. www.sciencedaily.com/releases/2009/02/090213115024.htm (accessed July 24, 2014).

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