Featured Research

from universities, journals, and other organizations

High-fat Diets Inflame Fat Tissue Around Blood Vessels, Contribute To Heart Disease

Date:
February 20, 2009
Source:
University of Cincinnati
Summary:
A new study shows that high-fat diets, even if consumed for a short amount of time, can inflame fat tissue surrounding blood vessels, possibly contributing to cardiovascular disease.

Neal Weintraub.
Credit: Image courtesy of University of Cincinnati

A study by researchers at the University of Cincinnati shows that high-fat diets, even if consumed for a short amount of time, can inflame fat tissue surrounding blood vessels, possibly contributing to cardiovascular disease.

Related Articles


These findings will be published in the Feb. 20 edition of the American Heart Association journal Circulation Research.

Neal Weintraub, MD, and colleagues examined adipose tissue—or fat—surrounding the coronary arteries of humans.  The researchers found these fat cells to be highly inflamed, suggesting that they could trigger inflammation of the blood vessels, an important component of atherosclerosis.

They also found that the inflammation of fat tissues around the arteries of mice is increased by feeding the animals a high-fat diet for just two weeks.

“This is independent of weight gain or blood lipids—cholesterol levels,” says Weintraub, senior author of the study and chair of the cardiovascular diseases division at UC.

Weintraub says that high fat diets contribute to atherosclerosis—or the hardening of arteries—in a number of ways.

“Elevated blood lipids—or cholesterol levels—can worsen with the intake of high fat diets, and this is known to contribute to atherosclerosis,” he says.  “However, many patients who consume high fat diets do not exhibit abnormal lipid profiles but still develop atherosclerosis nonetheless. 

“These new findings suggest a direct link between poor dietary habits and inflammation of blood vessels, mediated by the fat cells surrounding the blood vessel wall.”

Weintraub adds that the diet fed to the mouse models was not unlike the diets consumed by many Americans.

“It produced striking abnormalities of the fat tissue surrounding blood vessels in a very short period of time,” he says. “This is a warning to those who say there isn’t a problem because their weight and cholesterol levels are under control. Lipid profiles don’t hold all the answers.

“Bad dietary habits can lead to a number of problems, and this suggests that a high fat diet is detrimental in ways we didn’t previously understand.”

Weintraub says there is no real way to measure the effects of poor dietary habits on fat tissue surrounding blood vessels.

“We don’t know why these cells are so responsive to high-fat diets,” he says. “We must now conduct further experiments to answer these types of questions.”

Researchers in the division of transplant surgery at UC and in the emergency medicine department at UC and the University of Iowa Carver College of Medicine were also involved in this study.

This study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Cincinnati. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati. "High-fat Diets Inflame Fat Tissue Around Blood Vessels, Contribute To Heart Disease." ScienceDaily. ScienceDaily, 20 February 2009. <www.sciencedaily.com/releases/2009/02/090218142001.htm>.
University of Cincinnati. (2009, February 20). High-fat Diets Inflame Fat Tissue Around Blood Vessels, Contribute To Heart Disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/02/090218142001.htm
University of Cincinnati. "High-fat Diets Inflame Fat Tissue Around Blood Vessels, Contribute To Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2009/02/090218142001.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins