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Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7

Date:
March 4, 2009
Source:
American Society for Microbiology
Summary:
A new study suggests that normal human intestinal bacteria may inhibit the development of Shiga toxin 2 (Stx2), the toxin responsible for causing the more severe symptoms associated with food-borne disease, following Escherichia coli O157:H7 infection.

A new study suggests that normal human intestinal bacteria may inhibit the development of Shiga toxin 2 (Stx2), the toxin responsible for causing the more severe symptoms associated with food-borne disease, following Escherichia coli O157:H7 infection. 

Enterohemorrhagic E. coli O157:H7 causes food-borne disease with symptoms ranging from diarrhea and hemorrhagic colitis to potentially fatal hemolytic-uremic syndrome. Stx2 is released in the gut following oral ingestion of E. coli O157:H7 and is the main virulence factor responsible for the more serious complications from the disease. Despite what researchers already know about the role of Stx2 in the progression of the disease, how the molecules released by the normal intestinal bacteria impact Stx2 is largely unknown.

In the study Stx2 synthesis was analyzed following the growth of E. coli O157:H7 in contents collected from the large bowel of rats colonized with normal human intestinal bacteria. Results showed that extracellular molecules, produced in part by Bacteroides thetaiotaomicron (a predominant species of the normal human intestine), repressed Stx2 development.

"Our findings demonstrate for the first time the regulatory activity of a soluble factor produced by the complex human digestive microbiota on a bacterial virulence factor in a physiologically relevant context," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. de Sablet et al. Human Microbiota-Secreted Factors Inhibit Shiga Toxin Synthesis by Enterohemorrhagic Escherichia coli O157:H7. Infection and Immunity, 2008; 77 (2): 783 DOI: 10.1128/IAI.01048-08

Cite This Page:

American Society for Microbiology. "Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7." ScienceDaily. ScienceDaily, 4 March 2009. <www.sciencedaily.com/releases/2009/03/090304132521.htm>.
American Society for Microbiology. (2009, March 4). Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2009/03/090304132521.htm
American Society for Microbiology. "Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7." ScienceDaily. www.sciencedaily.com/releases/2009/03/090304132521.htm (accessed October 2, 2014).

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