Featured Research

from universities, journals, and other organizations

Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7

Date:
March 4, 2009
Source:
American Society for Microbiology
Summary:
A new study suggests that normal human intestinal bacteria may inhibit the development of Shiga toxin 2 (Stx2), the toxin responsible for causing the more severe symptoms associated with food-borne disease, following Escherichia coli O157:H7 infection.

A new study suggests that normal human intestinal bacteria may inhibit the development of Shiga toxin 2 (Stx2), the toxin responsible for causing the more severe symptoms associated with food-borne disease, following Escherichia coli O157:H7 infection.

Enterohemorrhagic E. coli O157:H7 causes food-borne disease with symptoms ranging from diarrhea and hemorrhagic colitis to potentially fatal hemolytic-uremic syndrome. Stx2 is released in the gut following oral ingestion of E. coli O157:H7 and is the main virulence factor responsible for the more serious complications from the disease. Despite what researchers already know about the role of Stx2 in the progression of the disease, how the molecules released by the normal intestinal bacteria impact Stx2 is largely unknown.

In the study Stx2 synthesis was analyzed following the growth of E. coli O157:H7 in contents collected from the large bowel of rats colonized with normal human intestinal bacteria. Results showed that extracellular molecules, produced in part by Bacteroides thetaiotaomicron (a predominant species of the normal human intestine), repressed Stx2 development.

"Our findings demonstrate for the first time the regulatory activity of a soluble factor produced by the complex human digestive microbiota on a bacterial virulence factor in a physiologically relevant context," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. de Sablet et al. Human Microbiota-Secreted Factors Inhibit Shiga Toxin Synthesis by Enterohemorrhagic Escherichia coli O157:H7. Infection and Immunity, 2008; 77 (2): 783 DOI: 10.1128/IAI.01048-08

Cite This Page:

American Society for Microbiology. "Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7." ScienceDaily. ScienceDaily, 4 March 2009. <www.sciencedaily.com/releases/2009/03/090304132521.htm>.
American Society for Microbiology. (2009, March 4). Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2009/03/090304132521.htm
American Society for Microbiology. "Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection With E. Coli O157:H7." ScienceDaily. www.sciencedaily.com/releases/2009/03/090304132521.htm (accessed August 2, 2014).

Share This




More Plants & Animals News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pyrenees Orphan Bear Cub Gets Brand New Home

Pyrenees Orphan Bear Cub Gets Brand New Home

AFP (Aug. 1, 2014) The discovery of a bear cub in the Pyrenees mountains made headlines in April 2014. Despire several attempts to find the animal's mother, the cub remained alone. Now, the Pyrenees Conservation Foundation has constructed an enclosure. Duration: 00:31 Video provided by AFP
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
Rare Whale Fossil Pulled from Calif. Backyard

Rare Whale Fossil Pulled from Calif. Backyard

AP (Aug. 1, 2014) A rare whale fossil has been pulled from a Southern California backyard. The 16- to 17-million-year-old baleen whale fossil is one of about 20 baleen whale fossils known to exist. (Aug. 1) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins