Featured Research

from universities, journals, and other organizations

Being Overweight Worsens Osteoarthritis

Date:
March 10, 2009
Source:
Arthritis Research & Therapy
Summary:
Being fat increases the risk of primary joint replacement in osteoarthritis. A new study found that increased waist circumference and body mass index were associated with the risk of both knee and hip joint replacement.

Being fat increases the risk of primary joint replacement in osteoarthritis (OA). A new study found that increased waist circumference and body mass index (BMI) were associated with the risk of both knee and hip joint replacement.

Related Articles


Total joint replacement is an effective treatment for severe knee and hip OA, and obesity is recognized as being the most important modifiable risk factor for OA. BMI is the most commonly used measurement of obesity but does not account for the pattern of fat distribution, and cannot discriminate between adipose and non-adipose tissue.

A research team headed by Flavia Cicuttini of the Monash University, Melbourne, Australia, conducted a prospective cohort study in 32,023 healthy volunteers to examine the relationship between different adiposity measures and the risk of subsequent primary knee and hip joint replacement. BMI, waist circumference and waist-to-hip ratios were measured, and fat mass and percentage fat were estimated.

The study determined that there was a 3 to 4-fold increased risk of primary joint replacement associated with body weight, BMI, fat mass and percentage fat. Waist circumference and waist-to-hip ratio were also associated with an increased risk, suggesting that both biomechanical and metabolic mechanisms associated with adiposity contribute to the risk of joint replacement. The group also showed that fat mass and percentage fat were associated with an increased risk of primary knee and hip joint replacement even 10 to 15 years after their measurement.

According to Cicuttini "Adipose mass contributes to increased joint loading, which may increase the risk of OA progression and subsequent joint replacement for severe end-stage OA. Metabolic factors are also likely to be important since waist circumference and waist-to-hip ratio are known risk factors for metabolic syndrome". She continues, "Adipose tissue is now considered an endocrine organ, releasing a multitude of factors, including cytokines which have been implicated in cartilage destruction".

The authors conclude, "The obesity epidemic occurring in developed countries is likely to have a significant impact on the future demands for knee and hip replacements for OA and understanding the mechanism of action will be important in effective prevention of OA".


Story Source:

The above story is based on materials provided by Arthritis Research & Therapy. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yuanyuan Wang, Julie Anne Simpson, Anita E Wluka, Andrew J Teichtahl, Dallas R English, Graham G Giles, Stephen Graves and Flavia M Cicuttini. Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study. Arthritis Research & Therapy, (in press)

Cite This Page:

Arthritis Research & Therapy. "Being Overweight Worsens Osteoarthritis." ScienceDaily. ScienceDaily, 10 March 2009. <www.sciencedaily.com/releases/2009/03/090305080145.htm>.
Arthritis Research & Therapy. (2009, March 10). Being Overweight Worsens Osteoarthritis. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2009/03/090305080145.htm
Arthritis Research & Therapy. "Being Overweight Worsens Osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2009/03/090305080145.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins