Featured Research

from universities, journals, and other organizations

Too Much Oxygen Not A Good Thing For Tumors

Date:
April 1, 2009
Source:
Journal of Clinical Investigation
Summary:
As tumors grow, some regions lack a blood supply adequate to maintain good levels of oxygen, that is some regions become hypoxic. This is a hallmark of malignant tumors and has been suggested, but not experimentally proven, to promote tumor progression.

As tumors grow, some regions lack a blood supply adequate to maintain good levels of oxygen, that is some regions become hypoxic. This is a hallmark of malignant tumors and has been suggested, but not experimentally proven, to promote tumor progression.

However, Paolo Michieli and colleagues, at the University of Turin Medical School, Italy, have now developed xenograft models to examine how human lung tumors without regions of hypoxia develop and found that tumors rely on hypoxia to promote their own expansion.

In the study, human lung cancer cells were engineered to express the protein myoglobin, which specializes in oxygen transport, storage, and buffering. When these cells were injected into mice, the tumors that developed exhibited no regions of hypoxia, and this was associated with both markedly reduced tumor growth and an inability to metastasize to secondary locations.

Further analysis confirmed that the effects were mainly a result of decreased tumor hypoxia, leading the authors to conclude that hypoxia seems to be a key factor driving tumor progression.

In an accompanying commentary, Ulrich Fl๖gel and Chi Dang, highlight the importance of these data and discus other ways in which myoglobin might affect tumor progression.

The research is published in the March 23, 2009, issue of the Journal of Clinical Investigation.



Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Maria Galluzzo, Selma Pennacchietti, Stefania Rosano, Paolo M. Comoglio and Paolo Michieli. Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI36579
  2. Ulrich Fl๖gel, Chi V. Dang. Myoglobin tames tumor growth and spread. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI38796

Cite This Page:

Journal of Clinical Investigation. "Too Much Oxygen Not A Good Thing For Tumors." ScienceDaily. ScienceDaily, 1 April 2009. <www.sciencedaily.com/releases/2009/03/090324213249.htm>.
Journal of Clinical Investigation. (2009, April 1). Too Much Oxygen Not A Good Thing For Tumors. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/03/090324213249.htm
Journal of Clinical Investigation. "Too Much Oxygen Not A Good Thing For Tumors." ScienceDaily. www.sciencedaily.com/releases/2009/03/090324213249.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins