Featured Research

from universities, journals, and other organizations

Solving The Mystery Of What Puts Sperm 'In The Mood'

Date:
April 15, 2009
Source:
American Chemical Society
Summary:
In a potential advance toward a male contraceptive pill and new treatments for infertility, researchers are reporting the identification of key biochemical changes that put sperm "in the mood" for fertilization.

Scientists report advances on understanding capacitation, which help put sperm "in the mood" for fertilization.
Credit: The American Chemical Society

In a potential advance toward a male contraceptive pill and new treatments for infertility, researchers are reporting the identification of key biochemical changes that put sperm "in the mood" for fertilization.

Related Articles


Mark Platt and colleagues note in the new study that sperm cannot fertilize an egg immediately after entering the female reproductive tract. Sperm must acquire this ability after undergoing an activation process called "capacitation." Scientists have known for years that this process involves phosphorylation. That common biological modification causes cellular activities to be turned "on" by the addition of phosphate molecules to certain amino acids within proteins. However, the specific biochemical details have been a deep mystery.

Using laboratory mice, the researchers compared the extent of phosphorylation in both capacitated and noncapacitated sperm samples. They identified 44 peptides exhibiting differential phosphorylation, on 59 specific amino acids, suggesting that modification of these particular sites is essential for the capacitation process. The relative ratio of phosphorylation between the capacitated and noncapacitated samples were also reported, providing the first biochemical description of what puts sperm "in the mood."


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Platt et al. Use of Differential Isotopic Labeling and Mass Spectrometry To Analyze Capacitation-Associated Changes in the Phosphorylation Status of Mouse Sperm Proteins. Journal of Proteome Research, 2009; 8 (3): 1431 DOI: 10.1021/pr800796j

Cite This Page:

American Chemical Society. "Solving The Mystery Of What Puts Sperm 'In The Mood'." ScienceDaily. ScienceDaily, 15 April 2009. <www.sciencedaily.com/releases/2009/04/090413102045.htm>.
American Chemical Society. (2009, April 15). Solving The Mystery Of What Puts Sperm 'In The Mood'. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2009/04/090413102045.htm
American Chemical Society. "Solving The Mystery Of What Puts Sperm 'In The Mood'." ScienceDaily. www.sciencedaily.com/releases/2009/04/090413102045.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins