Featured Research

from universities, journals, and other organizations

Solving The Mystery Of What Puts Sperm 'In The Mood'

Date:
April 15, 2009
Source:
American Chemical Society
Summary:
In a potential advance toward a male contraceptive pill and new treatments for infertility, researchers are reporting the identification of key biochemical changes that put sperm "in the mood" for fertilization.

Scientists report advances on understanding capacitation, which help put sperm "in the mood" for fertilization.
Credit: The American Chemical Society

In a potential advance toward a male contraceptive pill and new treatments for infertility, researchers are reporting the identification of key biochemical changes that put sperm "in the mood" for fertilization.

Related Articles


Mark Platt and colleagues note in the new study that sperm cannot fertilize an egg immediately after entering the female reproductive tract. Sperm must acquire this ability after undergoing an activation process called "capacitation." Scientists have known for years that this process involves phosphorylation. That common biological modification causes cellular activities to be turned "on" by the addition of phosphate molecules to certain amino acids within proteins. However, the specific biochemical details have been a deep mystery.

Using laboratory mice, the researchers compared the extent of phosphorylation in both capacitated and noncapacitated sperm samples. They identified 44 peptides exhibiting differential phosphorylation, on 59 specific amino acids, suggesting that modification of these particular sites is essential for the capacitation process. The relative ratio of phosphorylation between the capacitated and noncapacitated samples were also reported, providing the first biochemical description of what puts sperm "in the mood."


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Platt et al. Use of Differential Isotopic Labeling and Mass Spectrometry To Analyze Capacitation-Associated Changes in the Phosphorylation Status of Mouse Sperm Proteins. Journal of Proteome Research, 2009; 8 (3): 1431 DOI: 10.1021/pr800796j

Cite This Page:

American Chemical Society. "Solving The Mystery Of What Puts Sperm 'In The Mood'." ScienceDaily. ScienceDaily, 15 April 2009. <www.sciencedaily.com/releases/2009/04/090413102045.htm>.
American Chemical Society. (2009, April 15). Solving The Mystery Of What Puts Sperm 'In The Mood'. ScienceDaily. Retrieved December 27, 2014 from www.sciencedaily.com/releases/2009/04/090413102045.htm
American Chemical Society. "Solving The Mystery Of What Puts Sperm 'In The Mood'." ScienceDaily. www.sciencedaily.com/releases/2009/04/090413102045.htm (accessed December 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Newsy (Dec. 26, 2014) If patients had led healthier lifestyles, Cancer Research UK found about 40 percent of cancer cases could have been prevented. Video provided by Newsy
Powered by NewsLook.com
When Healthy Eating Becomes Dangerous

When Healthy Eating Becomes Dangerous

Newsy (Dec. 26, 2014) Experts say fad diets can lead to orthorexia, a disorder that can cause physical and emotional distress. Video provided by Newsy
Powered by NewsLook.com
FDA Issues New Warning About Pure Caffeine Powder Usage

FDA Issues New Warning About Pure Caffeine Powder Usage

Newsy (Dec. 24, 2014) The FDA cites two deaths this year linked to pure caffeine powder as warnings of the potentially fatal substance. Video provided by Newsy
Powered by NewsLook.com
Alarming CDC Lab Report Reveals Ebola Sample Mix-Up

Alarming CDC Lab Report Reveals Ebola Sample Mix-Up

Newsy (Dec. 24, 2014) The Centers for Disease Control and Prevention released a report claiming a lab tech in Atlanta might have been exposed to the Ebola virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins