Featured Research

from universities, journals, and other organizations

Uncovering Secrets Of Salmonella's Stealth Attack

Date:
April 17, 2009
Source:
Yale University
Summary:
A single crafty protein allows the deadly bacterium Salmonella enterica to both invade cells lining the intestine and hijack cellular functions to avoid destruction. This evolutionary slight-of-hand sheds new insights into the lethal tricks of Salmonella, which kills more than 2 million people a year.

A single crafty protein allows the deadly bacterium Salmonella enterica to both invade cells lining the intestine and hijack cellular functions to avoid destruction, Yale researchers report in the April 17 issue of the journal Cell.

Related Articles


This evolutionary slight-of-hand sheds new insights into the lethal tricks of Salmonella, which kills more than 2 million people a year.

"In evolutionary terms, this hijacking of cellular machinery to diversify the function of a bacterial protein is mind boggling,'' said Jorge Galan, senior author of the paper and the Lucille P. Markey Professor of Microbial Pathogenesis and Cell Biology and chair of microbial pathogenesis at Yale.

Salmonella causes disease when it takes control of cells lining the intestinal track using its own specialized "nano-syringe" called a type III secretion system. Using this structure, Salmonella injects bacterial proteins that mimic proteins of the host cell and help the pathogen avoid destruction.

The Yale study describes the crucial role a bacterial protein called SopB plays in both Salmonella's forced entry into the cell and its subsequent internal camouflage act. First, SopB works within the external membrane of the cell, called the plasma membrane, to coax the cell into taking in the pathogen, which is then encapsulated within a tiny bubble-like compartment called a vesicle.

SopB's second trick helps prevent the vesicle from being sucked into the lyosome, the organelle within the cell that degrades proteins. In order to accomplish this, SopB must move from the plasma membrane of the cell to the membrane of the internal vesicle containing the pathogen. The Yale group found that Salmonella coaxes the cell to "mark" the SopB protein with a tag called ubiquitin. Addition of this tag makes the bacterial protein recognizable to the cellular machinery that normally moves proteins from the plasma membranes to internal vesicles.

"These studies provide a unique insight into the mechanisms by which this important pathogen causes disease," Galan said. "In addition, this finding may point to a novel paradigm that may be applicable to other important pathogens."

Other Yale authors of the paper are Jayesh C. Patel, Karsten Hueffer, and Tukiet T. Lam.

The study was funded by a grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Uncovering Secrets Of Salmonella's Stealth Attack." ScienceDaily. ScienceDaily, 17 April 2009. <www.sciencedaily.com/releases/2009/04/090416125203.htm>.
Yale University. (2009, April 17). Uncovering Secrets Of Salmonella's Stealth Attack. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/04/090416125203.htm
Yale University. "Uncovering Secrets Of Salmonella's Stealth Attack." ScienceDaily. www.sciencedaily.com/releases/2009/04/090416125203.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins