Featured Research

from universities, journals, and other organizations

New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models

Date:
April 23, 2009
Source:
American Society for Microbiology
Summary:
A new experimental Ebola vaccine is one step closer to realization, having proven its ability to protect against lethal infections in animal models.

A new experimental Ebola vaccine is one step closer to realization, having proven its ability to protect against lethal infections in animal models.

Related Articles


Ebolaviruses (EBOVs), the cause of severe hemorrhagic fever in humans and nonhuman primates, are transmitted through direct contact of bodily fluids with infected individuals resulting in death up to 90% of the time. Due to its high pathogenicity and its ability to spread by aerosol droplets, EBOV and its sister virus, Marburgvirus, are classified as category A bioterrorism threats. Currently, no licensed vaccines or antivirals are available against EBOV.

In a previous study the researchers developed a replication-deficient, biologically contained EBOV, EbolaδVP30, vaccine candidate which lacks the essential VP30 gene. In this study they demonstrated its safety in STAT-1 knockout-mice and evaluated its protective efficacy in mice and guinea pigs. Results showed that mice receiving two inoculations with EbolaδVP30 were protected against lethal infection with a mouse-adapted EBOV and viral levels in the blood of vaccinated mice were noticeably lower that those in nonvaccinated mice. Additionally, guinea pigs immunized twice with EbolaδVP30 were also protected against lethal infection with a guinea pig adapted EBOV.

"Our study demonstrates the potential of the EbolaδVP30 virus as a new vaccine platform," say the researchers. "As with other EBOV vaccine candidates, our vaccine would be of value to health care personnel, laboratory workers, and military personnel, as well as those at risk during outbreaks."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Halfmann et al. Replication-Deficient Ebolavirus as a Vaccine Candidate. Journal of Virology, 2009; 83 (8): 3810 DOI: 10.1128/JVI.00074-09

Cite This Page:

American Society for Microbiology. "New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models." ScienceDaily. ScienceDaily, 23 April 2009. <www.sciencedaily.com/releases/2009/04/090421142410.htm>.
American Society for Microbiology. (2009, April 23). New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2009/04/090421142410.htm
American Society for Microbiology. "New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models." ScienceDaily. www.sciencedaily.com/releases/2009/04/090421142410.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Brawling Pandas Are Violently Adorable

Brawling Pandas Are Violently Adorable

Buzz60 (Jan. 29, 2015) Video of pandas play fighting at the Chengdu Research Base in China will make your day. Mara Montalbano (@maramontalbano) shows us. Video provided by Buzz60
Powered by NewsLook.com
Why Researchers Say We Should Cut Back On Biofuels

Why Researchers Say We Should Cut Back On Biofuels

Newsy (Jan. 29, 2015) Biofuels aren&apos;t the best alternative to fossil fuels, according to a new report. In fact, they&apos;re quite a bad one. Video provided by Newsy
Powered by NewsLook.com
3-D Printed Wheelchair Helps Two-Legged Dog Learn to Run

3-D Printed Wheelchair Helps Two-Legged Dog Learn to Run

Buzz60 (Jan. 29, 2015) 3-D printing helps another two-legged dog run around with his four-legged friends. Jen Markham (@jenmarkham) has the adorable video. Video provided by Buzz60
Powered by NewsLook.com
Dogs Bring on So Many Different Emotions in Their Human Best Friends

Dogs Bring on So Many Different Emotions in Their Human Best Friends

RightThisMinute (Jan. 28, 2015) From new-puppy happy tears to helpful-grocery-carrying-dog laughter, our four-legged best friends can make us feel the entire spectrum of emotions. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins