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New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models

Date:
April 23, 2009
Source:
American Society for Microbiology
Summary:
A new experimental Ebola vaccine is one step closer to realization, having proven its ability to protect against lethal infections in animal models.

A new experimental Ebola vaccine is one step closer to realization, having proven its ability to protect against lethal infections in animal models.

Ebolaviruses (EBOVs), the cause of severe hemorrhagic fever in humans and nonhuman primates, are transmitted through direct contact of bodily fluids with infected individuals resulting in death up to 90% of the time. Due to its high pathogenicity and its ability to spread by aerosol droplets, EBOV and its sister virus, Marburgvirus, are classified as category A bioterrorism threats. Currently, no licensed vaccines or antivirals are available against EBOV.

In a previous study the researchers developed a replication-deficient, biologically contained EBOV, EbolaδVP30, vaccine candidate which lacks the essential VP30 gene. In this study they demonstrated its safety in STAT-1 knockout-mice and evaluated its protective efficacy in mice and guinea pigs. Results showed that mice receiving two inoculations with EbolaδVP30 were protected against lethal infection with a mouse-adapted EBOV and viral levels in the blood of vaccinated mice were noticeably lower that those in nonvaccinated mice. Additionally, guinea pigs immunized twice with EbolaδVP30 were also protected against lethal infection with a guinea pig adapted EBOV.

"Our study demonstrates the potential of the EbolaδVP30 virus as a new vaccine platform," say the researchers. "As with other EBOV vaccine candidates, our vaccine would be of value to health care personnel, laboratory workers, and military personnel, as well as those at risk during outbreaks."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Halfmann et al. Replication-Deficient Ebolavirus as a Vaccine Candidate. Journal of Virology, 2009; 83 (8): 3810 DOI: 10.1128/JVI.00074-09

Cite This Page:

American Society for Microbiology. "New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models." ScienceDaily. ScienceDaily, 23 April 2009. <www.sciencedaily.com/releases/2009/04/090421142410.htm>.
American Society for Microbiology. (2009, April 23). New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/04/090421142410.htm
American Society for Microbiology. "New Ebolavirus Vaccine Protects Against Lethal Infection in Animal Models." ScienceDaily. www.sciencedaily.com/releases/2009/04/090421142410.htm (accessed September 20, 2014).

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