Featured Research

from universities, journals, and other organizations

Antioxidant Found In Berries, Other Foods Prevents UV Skin Damage That Leads To Wrinkles

Date:
April 23, 2009
Source:
Federation of American Societies for Experimental Biology
Summary:
Using a topical application of the antioxidant ellagic acid, researchers markedly prevented collagen destruction and inflammatory response -- major causes of wrinkles -- in both human skin cells and the sensitive skin of hairless mice following continuing exposure to UV-B, the sun's skin-damaging ultraviolet radioactive rays.

Using a topical application of the antioxidant ellagic acid, researchers markedly prevented collagen destruction and inflammatory response – major causes of wrinkles -- in both human skin cells and the sensitive skin of hairless mice following continuing exposure to UV-B, the sun's skin-damaging ultraviolet radioactive rays.
Credit: iStockphoto/Renars Jurkovskis

Using a topical application of the antioxidant ellagic acid, researchers at Hallym University in the Republic of Korea markedly prevented collagen destruction and inflammatory response – major causes of wrinkles -- in both human skin cells and the sensitive skin of hairless mice following continuing exposure to UV-B, the sun's skin-damaging ultraviolet radioactive rays.

Ji-Young Bae, a graduate student in the laboratory of Dr. Young-Hee Kang, presented results of the two-part study on Tuesday, April 21, at the Experimental Biology 2009 meeting in New Orleans. The presentation was part of the scientific program of the American Society for Nutrition.

Ellagic acid is an antioxidant found in numerous fruits, vegetables and nuts, especially raspberries, strawberries, cranberries and pomegranates. Earlier studies have suggested it has a photoprotective effect.

But how? The Kang laboratory found that, in human skin cells, ellagic acid worked to protect against UV damage by blocking production of MMP (matrix metalloproteinase enzymes that break down collagen in damaged skin cells) and by reducing the expression of ICAM (a molecule involved in inflammation).

The scientists then turned to young (four weeks), male, hairless mice - genetically bred types of mice often used in dermatology studies because of the physiological similarities of their skin to that of humans. For eight weeks, the 12 mice were exposed to increasing ultraviolet radiation, such as that found in sunlight, three times a week, beginning at a level sufficient to cause redness or sunburn and increasing to a level that would have definitely caused minor skin damage to human skin.

During these eight weeks, half of the exposed mice were given daily 10 microM topical applications of ellagic acid on their skin surface, even on the days in which they did not receive UV exposure. The other mice, also exposed to UV light, did not receive ellagic acid. (Another six mice served as controls, with neither UV exposure nor ellagic acid.)

What happened? First, as expected, the mice exposed to UV radiation without the ellagic acid treatment developed wrinkles and thickening of the skin.

Second, as hypothesized, the exposed mice that received topical application of ellagic acid showed reduced wrinkle formation.

Third, as suggested in the study of human cells, the ellagic acid reduced inflammatory response and MMP secretion due to protection from the degradation of collagen. The ellagic acid also helped prevent an increase of epidermal thickness

The researchers say the results demonstrate that ellagic acid works to prevent wrinkle formation and photo-aging caused by UV destruction of collagen and inflammatory response.

In addition to Ji-Young Bae and Dr. Young-Hee Kang, co-authors were Jung-Suk Choi, Sang-Wook Kang, Dong Shoo Kim, and Jung Lye Kim. The research was supported by the Korea Research Foundation and Brain Korea 21.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Antioxidant Found In Berries, Other Foods Prevents UV Skin Damage That Leads To Wrinkles." ScienceDaily. ScienceDaily, 23 April 2009. <www.sciencedaily.com/releases/2009/04/090421154318.htm>.
Federation of American Societies for Experimental Biology. (2009, April 23). Antioxidant Found In Berries, Other Foods Prevents UV Skin Damage That Leads To Wrinkles. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/04/090421154318.htm
Federation of American Societies for Experimental Biology. "Antioxidant Found In Berries, Other Foods Prevents UV Skin Damage That Leads To Wrinkles." ScienceDaily. www.sciencedaily.com/releases/2009/04/090421154318.htm (accessed October 1, 2014).

Share This



More Plants & Animals News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cultural Learning In Wild Chimps Observed For The First Time

Cultural Learning In Wild Chimps Observed For The First Time

Newsy (Oct. 1, 2014) — Cultural transmission — the passing of knowledge from one animal to another — has been caught on camera with chimps teaching other chimps. Video provided by Newsy
Powered by NewsLook.com
Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) — A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Dolphins Might Use Earth's Magnetic Field As A GPS

Dolphins Might Use Earth's Magnetic Field As A GPS

Newsy (Sep. 30, 2014) — A study released Monday suggests dolphins might be able to sense the Earth's magnetic field and possibly use it as a means of navigation. Video provided by Newsy
Powered by NewsLook.com
How To Battle Stink Bug Season

How To Battle Stink Bug Season

Newsy (Sep. 30, 2014) — Homeowners in 33 states grapple with stink bugs moving indoors at this time of year. Here are a few tips to avoid stink bug infestations. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins