Featured Research

from universities, journals, and other organizations

Rifampin Kinetics Poor In Children, Study Suggests

Date:
April 21, 2009
Source:
BMC Medicine
Summary:
Rifampin, a first-line antituberculosis drug, reaches serum concentrations well below suggested lower limits when a standard dose of 8-12mg/kg body weight is given to children. A pharmacokinetic study suggests that a higher dose of 10-20mg/kg may be more appropriate.

Rifampin (RMP), a first-line antituberculosis drug, reaches serum concentrations well below suggested lower limits when a standard dose of 8-12mg/kg body weight is given to children. A pharmacokinetic study suggests that a higher dose of 10-20mg/kg may be more appropriate.

H. Simon Schaaf from the University of Stellenbosch, South Africa, led a team of researchers who studied 54 children admitted to hospital with severe tuberculosis, 21 of whom also had HIV infection. He said, "The mean calculated 2h RMP concentrations in these HIV-infected and HIV-uninfected children were 3.9 and 4.8μg/ml, respectively, at 1-month after treatment start and 4.0 and 4.6μg/ml after 4-months treatment. These values are considerably less than the suggested lower limit for 2h RMP concentrations in adults of 8.0μg/ml".

Although there is some evidence that the low concentrations achieved may be effective in treating tuberculosis, Schaaf and his colleagues sound a note of caution regarding the more severe forms of tuberculosis such as are increasingly encountered in the developing world, especially in association with HIV infection. They write, "In the era of HIV/AIDS, any reduction in the dose of antituberculosis agents reflected by frequency and length of treatment, particularly in more severe forms of pulmonary tuberculosis, may be associated with an increased risk of relapse".

The dosage of RMP recommended for use in children in the United States of America is 15mg/kg with a range of 10-20mg/kg body weight. The authors conclude that this should be the standard globally, "We believe that the recommended RMP dose of 10-20 mg/kg for children by the American Academy of Pediatrics is a more appropriate dosage range".


Story Source:

The above story is based on materials provided by BMC Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hendrik Simon Schaaf, Marianne Willemse, Karien Cilliers, Demetre Labadarios, Johannes Stephanus Maritz, Gregory D Hussey, Helen McIlleron, Peter Smith and Peter Roderick Donald. Rifampin pharmacokinetics in children, with and without human immunodeficiency virus infection, hospitalized for the management of severe forms of tuberculosis. BMC Medicine, (in press)

Cite This Page:

BMC Medicine. "Rifampin Kinetics Poor In Children, Study Suggests." ScienceDaily. ScienceDaily, 21 April 2009. <www.sciencedaily.com/releases/2009/04/090421205242.htm>.
BMC Medicine. (2009, April 21). Rifampin Kinetics Poor In Children, Study Suggests. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/04/090421205242.htm
BMC Medicine. "Rifampin Kinetics Poor In Children, Study Suggests." ScienceDaily. www.sciencedaily.com/releases/2009/04/090421205242.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins