Featured Research

from universities, journals, and other organizations

German Researchers Make Significant Strides In Identifying Cause Of Bacterial Infections

Date:
April 29, 2009
Source:
Helmholtz Association of German Research Centres
Summary:
Several bacterial pathogens use toxins to manipulate human host cells, ultimately disturbing cellular signal transduction. Until now, however, scientists have been able to track down only a few of the proteins that interact with bacterial toxins in infected human cells. Now, researchers in Germany have identified 39 interaction partners of these toxins, using novel technology which allowed them to screen for large numbers of proteins simultaneously.

Several bacterial pathogens use toxins to manipulate human host cells, ultimately disturbing cellular signal transduction. Until now, however, scientists have been able to track down only a few of the proteins that interact with bacterial toxins in infected human cells.

Now, researchers of the Max Planck Institute of Biochemistry in Martinsried and the Max Delbrόck Center for Molecular Medicine (MDC) Berlin-Buch in Germany have identified 39 interaction partners of these toxins, using novel technology which allowed them to screen for large numbers of proteins simultaneously.

Many bacteria inject toxins into human cells using a secretion system that resembles a molecular syringe. Within the host cell, some of these toxins are activated in such a way that they can manipulate important cellular signaling pathways. In healthy cells, these signals serve to regulate metabolism or cell division, among other things. By manipulating the signals, bacteria can abuse the cell machinery of the human host in order to spread and survive.

Applying a method developed by Professor Matthias Mann of the MPI, the scientists succeeded for the first time in systematically investigating the cellular target sites of the bacterial toxins. "Surprisingly, the toxins are not optimally adapted to the structures of human proteins," Dr. Matthias Selbach of MDC explained. While binding relatively weakly to individual human proteins, they are able to influence several different proteins simultaneously. "A single bacterial toxin seems to function like a master key that can access different host cell proteins in parallel", Dr. Selbach said. "Perhaps it is due to this strategy that bacteria are able to attack very different cells and, thus, to increase their survival chances in the host."

Dr. Selbach hopes that these basic research findings will help to improve the treatment of bacterial infections in the future. Instead of nonspecific antibiotic therapy, new drugs could target the signaling mechanisms which are disrupted by the bacterial toxins.


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matthias Selbach, Florian Ernst Paul, Sabine Brandt, Patrick Guye, Oliver Daumke, Steffen Backert, Christoph Dehio, and Matthias Mann. Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins. Cell Host & Microbe, 2009; 5 (4): 397-403 DOI: 10.1016/j.chom.2009.03.004

Cite This Page:

Helmholtz Association of German Research Centres. "German Researchers Make Significant Strides In Identifying Cause Of Bacterial Infections." ScienceDaily. ScienceDaily, 29 April 2009. <www.sciencedaily.com/releases/2009/04/090422121856.htm>.
Helmholtz Association of German Research Centres. (2009, April 29). German Researchers Make Significant Strides In Identifying Cause Of Bacterial Infections. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/04/090422121856.htm
Helmholtz Association of German Research Centres. "German Researchers Make Significant Strides In Identifying Cause Of Bacterial Infections." ScienceDaily. www.sciencedaily.com/releases/2009/04/090422121856.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) — Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) — Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) — He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) — An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins