Featured Research

from universities, journals, and other organizations

Mechanism Behind Delayed Development Of Antibiotic Resistance Explained

Date:
May 7, 2009
Source:
Uppsala University
Summary:
Inhibiting the "drug efflux pumps" in bacteria, which function as their defense mechanisms against antibiotics, can mask the effect of mutations that have led to antibiotic resistance. This can provide clues to how the development of resistance to antibiotics in bacteria can be delayed.

Inhibiting the "drug efflux pumps" in bacteria, which function as their defence mechanisms against antibiotics, can mask the effect of mutations that have led to resistance in the form of low-affinity drug binding to target molecules in the cell. This is shown by researchers at Uppsala University in a new study that can provide clues to how the development of resistance to antibiotics in bacteria can be delayed.

The introduction of antibiotics as drugs in the treatment of bacterial infections in the post-WWII years was a revolutionized medicine, and dramatically improved the health condition on a global scale. Now, 60 years later, growing antibiotic resistance among pathogens has heavily depleted the arsenal of entailed effective antibiotic drugs.

Antibiotics function by attacking vital molecules in bacteria. Bacteria, in turn, protect themselves either by using "drug efflux pumps" for antibiotics or through mutations that reduce the binding of the antibiotic to its target molecules inside the bacteria cell. Through these changes, bacteria develop resistance to antibiotics.

The new study is published in the journal Proceedings of the National Academy of Sciences in the US. Professor Måns Ehrenberg's research team at Uppsala University has shown experimentally and theoretically explained how the inhibition of these drug efflux pumps can completely mask the resistance effect of mutations that reduce the affinity of antibiotics to their target molecules in the bacteria cell. The effect of the mutations is entirely hidden when the pumps are unable to remove the antibiotic sufficiently quickly in relation to the dilution of the antibiotic through cell growth and cell division.

"This masking effect can provide clues to how the development of resistance to antibiotics in bacteria can be delayed," says Måns Ehrenberg.

The study introduces a new tool for understanding and delaying the development of resistance in bacteria.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Cite This Page:

Uppsala University. "Mechanism Behind Delayed Development Of Antibiotic Resistance Explained." ScienceDaily. ScienceDaily, 7 May 2009. <www.sciencedaily.com/releases/2009/05/090505153629.htm>.
Uppsala University. (2009, May 7). Mechanism Behind Delayed Development Of Antibiotic Resistance Explained. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/05/090505153629.htm
Uppsala University. "Mechanism Behind Delayed Development Of Antibiotic Resistance Explained." ScienceDaily. www.sciencedaily.com/releases/2009/05/090505153629.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) — Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) — He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) — An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Adorable Video of Baby Rhino and Lamb Friend Playing

Adorable Video of Baby Rhino and Lamb Friend Playing

Buzz60 (Oct. 20, 2014) — Gertjie the Rhino and Lammie the Lamb are teaching the world about animal conservation and friendship. TC Newman (@PurpleTCNewman) has the adorable video! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins