Featured Research

from universities, journals, and other organizations

Tumor Growth Predicted With Mathematical Model

Date:
May 12, 2009
Source:
University of Granada
Summary:
Researchers have found a mathematical model that will allow them to carry out experiments on tumor cell proliferation processes and find out their behavior. ‘Acting on the cell-cell communication process to try to control gene activation or deactivation may become an alternative therapy to fight tumor growth in the near future’, explained the director of the research.

Researchers from the University of Granada (on the fields of biology, chemistry, medicine and physics) have found a math model that will allow them to carry out experiments on tumour cell proliferation processes and find out their behaviour. ‘Acting on the cell-cell communication process to try to control gene activation or deactivation may become an alternative therapy to fight tumour growth in the near future’, explained Juan Soler, director of the research.

The work, led by Soler, from the Departamento de Matemαtica Aplicada de la UGR, will allow improving traditional tests with animal models, which were until now the key to describe tumour growth mechanisms. Moreover, with this tool researchers can carry out experiments changing the variables that are present in the biological process with more control and in coordination with clinical trials. This will make research in the field of tumour growth easier, and will save tests with embryos, mice or chickens, which were essential until now.

This model is specific to reproduce the tumour cell-cell communication process and reproduces with great accuracy all the mechanisms of chemical signal transmission, the cell reception of such signals and changes of the cellular functions resulting from such communication. All this has been achieved by using differential equations to describe each variable used which are integrated by means of complex equation systems that, once resolved, are contrasted with the results of the same processes in a real model. This way, the model is adjusted and readjusted until it does represent the biological process requested.

The mathematical advance necessary for the development of the model has been complemented by wide research work into the fields of biology and cellular physiology. More specifically, cellular communication chemical mechanisms deriving from the Sonic Hedgehog (SHH) protein and its equivalent in flies, called HH, which play an important function in the spreading of information on the growth and development of cellular groups. The function this protein plays when it activates the GLI gene -which in turn affect tumour control- has been analysed.

In different experiments, scientists, in collaboration with Molecular Biology centre Severo Ochoa and the University of Geneva, have proven that SHH transport control can make mice in vivo inoculated tumours disappear.

This research was funded with 150,900 euros by the Andalusian Ministry for Innovation.


Story Source:

The above story is based on materials provided by University of Granada. Note: Materials may be edited for content and length.


Cite This Page:

University of Granada. "Tumor Growth Predicted With Mathematical Model." ScienceDaily. ScienceDaily, 12 May 2009. <www.sciencedaily.com/releases/2009/05/090512093410.htm>.
University of Granada. (2009, May 12). Tumor Growth Predicted With Mathematical Model. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/05/090512093410.htm
University of Granada. "Tumor Growth Predicted With Mathematical Model." ScienceDaily. www.sciencedaily.com/releases/2009/05/090512093410.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) — Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins