Featured Research

from universities, journals, and other organizations

Environmental Exposure To Particulates May Damage DNA In As Few As Three Days

Date:
May 18, 2009
Source:
American Thoracic Society
Summary:
Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.

Smog and fog over Milan, Italy. New research shows that inhaling certain particulates can actually cause some genes to become reprogrammed in a matter of days.
Credit: iStockphoto

Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.

The research will be presented on May 17, at the 105th International Conference of the American Thoracic Society in San Diego.

"Recently, changes in gene programming due to a chemical transformation called methylation have been found in the blood and tissues of lung cancer patients," said investigator Andrea Baccarelli, M.D., Ph.D., assistant professor of applied biotechnology at the University of Milan. "We aimed at investigating whether exposure to particulate matter induced changes in DNA methylation in blood from healthy subjects who were exposed to high levels of particulate matter in a foundry facility."

Researchers enrolled 63 healthy subjects who worked in a foundry near Milan, Italy. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor suppression.

"The changes were detectable after only three days of exposure to particulate matter, indicating that environmental factors need little time to cause gene reprogramming which is potentially associated with disease outcomes," Dr. Baccarelli said.

"As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health," he added. "The changes in DNA methylation we observed are reversible and some of them are currently being used as targets of cancer drugs."

Dr. Baccarelli said the study results indicate that early interventions might be designed which would reverse gene programming to normal levels, reducing the health risks of exposure.

"We need to evaluate how the changes in gene reprogramming we observed are related to cancer risk," he said. "Down the road, it will be particularly important not only to show that these changes are associated with increased risk of cancer or other environmentally-induced diseases, but that, if we were able to prevent or revert them, these risks could be eliminated."

Session # A45: "Genetic Basis for Environmental and Occupational Respiratory Diseases." Abstract # 2589: "Effects of Particulate Matter Exposure on p16, p53, APC and RASSF1A Promoter Methylation" Poster Board # C51


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Environmental Exposure To Particulates May Damage DNA In As Few As Three Days." ScienceDaily. ScienceDaily, 18 May 2009. <www.sciencedaily.com/releases/2009/05/090517143218.htm>.
American Thoracic Society. (2009, May 18). Environmental Exposure To Particulates May Damage DNA In As Few As Three Days. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2009/05/090517143218.htm
American Thoracic Society. "Environmental Exposure To Particulates May Damage DNA In As Few As Three Days." ScienceDaily. www.sciencedaily.com/releases/2009/05/090517143218.htm (accessed August 29, 2014).

Share This




More Earth & Climate News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Volcano Erupts on Papua New Guinea

Raw: Volcano Erupts on Papua New Guinea

AP (Aug. 29, 2014) Several communities were evacuated and some international flights were diverted on Friday after one of the most active volcanos in the region erupts. (Aug. 29) Video provided by AP
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Scientists Have Figured Out Why Rocks Move In Death Valley

Scientists Have Figured Out Why Rocks Move In Death Valley

Newsy (Aug. 28, 2014) The mystery of the moving rocks in Death Valley, California, has finally been solved. Scientists are pointing to a combo of water, ice and wind. Video provided by Newsy
Powered by NewsLook.com
Big Waves, Minor Flooding from Hurricane

Big Waves, Minor Flooding from Hurricane

AP (Aug. 27, 2014) Thundering surf spawned by Hurricane Marie pounded the Southern California coast Wednesday, causing minor flooding in a low-lying beach town. High surf warnings were posted for Los Angeles County south through Orange County. (Aug. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins