Featured Research

from universities, journals, and other organizations

Novel Markers For Kidney Disease Progression

Date:
May 22, 2009
Source:
American Journal of Pathology
Summary:
Scientists have established novel markers of kidney disease progression.

A group led by Drs. Erwin P. Böttinger of the Mount Sinai School of Medicine and Matthias Kretzler at the University of Michigan have established novel markers of kidney disease progression.

Related Articles


Chronic kidney disease may affect up to 16.8% of the US population. Only a minority of patients with chronic kidney disease progress to end-stage renal disease. However, current clinical markers are not sufficient to reliably predict chronic kidney disease progression, which would allow for targeted treatment of high-risk patients.

To identify markers of chronic kidney disease progression, Ju et al screened a mouse model of progressive renal disease to identify genes whose expression correlated with renal disease severity. They then examined human versions of these genes, and found that a subset of these candidates were associated with disease progression and glomerular filtration rate in human patients.

The biomarkers identified by Dr. Böttinger, Dr. Kretzler, and colleagues "predict progressive renal fibrosis in mice and may [therefore] be useful molecular predictors of [chronic kidney disease] progression in humans."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ju W, Eichinger F, Bitzer M, Oh J, McWeeney S, Berthier CC, Shedden K, Cohen CD, Henger A, Krick S, Kopp JB, Stoeckert Jr. CJ, Dikman S, Schröppel B, Thomas DB, Schlondorff D, Kretzler M, Böttinger EP. Renal Gene and Protein Expression Signatures for Prediction of Kidney Disease Progression. Am J Pathol, 2009, 174: 2073-2085

Cite This Page:

American Journal of Pathology. "Novel Markers For Kidney Disease Progression." ScienceDaily. ScienceDaily, 22 May 2009. <www.sciencedaily.com/releases/2009/05/090522113121.htm>.
American Journal of Pathology. (2009, May 22). Novel Markers For Kidney Disease Progression. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2009/05/090522113121.htm
American Journal of Pathology. "Novel Markers For Kidney Disease Progression." ScienceDaily. www.sciencedaily.com/releases/2009/05/090522113121.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins