Featured Research

from universities, journals, and other organizations

Estrogen Linked To Lowered Immunity In Fish

Date:
June 4, 2009
Source:
United States Geological Survey
Summary:
Exposure to estrogen reduces production of immune-related proteins in fish. This suggests that certain compounds, known as endocrine disruptors, may make fish more susceptible to disease. The research may provide new clues for why intersex fish, fish kills and fish lesions often occur together in the Shenandoah and Potomac rivers.

Exposure to estrogen reduces production of immune-related proteins in fish. This suggests that certain compounds, known as endocrine disruptors, may make fish more susceptible to disease.

Related Articles


The research may provide new clues for why intersex fish, fish kills and fish lesions often occur together in the Shenandoah and Potomac rivers. The tests were conducted in a lab by scientists from the U.S. Geological Survey.

The study, led by USGS genomics researcher Dr. Laura Robertson, revealed that largemouth bass injected with estrogen produced lowered levels of hepcidin, an important iron-regulating hormone in mammals that is also found in fish and amphibians. This is the first published study demonstrating control of hepcidin by estrogen in any animal.

Besides being an important iron-regulating hormone, researchers also suspect that hepcidin may act as an antimicrobial peptide in mammals, fish and frogs. Antimicrobial peptides are the first line of defense against disease-causing bacteria and some fungi and viruses in vertebrate animals.

“Our research suggests that estrogen-mimicking compounds may make fish more susceptible to disease by blocking production of hepcidin and other immune-related proteins that help protect fish against disease-causing bacteria,” said Robertson.

USGS researchers Drs. Vicki Blazer and Luke Iwanowicz have previously found intersex occurring in fish in the Potomac and Shenandoah rivers. Intersex is primarily revealed in male fish that have immature female egg cells in their testes. Because other studies have shown that estrogen and estrogen-mimicking compounds can cause intersex, the co-occurrence of fish lesions, fish kills and intersex in these two rivers suggested to USGS scientists that estrogen-mimicking compounds could be involved in the fish lesions and fish kills in addition to being a possible cause of intersex traits.

That caused Robertson and her colleagues to investigate how estrogen could be affecting the immune system in these fish. The study showed that largemouth bass produced two different hepcidin proteins. Production of the first hepcidin protein was “turned down” by estrogen. Production of the second hepcidin protein by fish exposed to bacteria was blocked by estrogen. The fact that estrogen blocked production of hepcidins in fish exposed to bacteria gives more weight to the theory that estrogen or estrogen-mimicking chemicals could be making fish more susceptible to diseases, Robertson added.

Hepcidin could protect against bacterial infection in two ways. “First,” said Robertson, “hepcidin could be an antimicrobial peptide that actually kills pathogens. Or it could be more complex. To live, a microbe must have iron, so when a microbe invades a person or animal, that microbe must obtain iron from its host. To ‘fight’ the microbe, a host can ‘suck up iron’ and store it in places inaccessible to the microbe. In mammals, hepcidin is a key player in how the host takes up and stores iron.”

The study, Identification of centrarchid hepcidins and evidence that 17β-estradiol disrupts constitutive expression of hepcidin-1 and inducible expression of hepcidin-2 in largemouth bass (Micropterus salmoides), was just published in the journal, Fish & Shellfish Immunology. The authors are USGS scientists Laura Robertson, Luke Iwanowicz and Jamie Marie Marranca.


Story Source:

The above story is based on materials provided by United States Geological Survey. Note: Materials may be edited for content and length.


Cite This Page:

United States Geological Survey. "Estrogen Linked To Lowered Immunity In Fish." ScienceDaily. ScienceDaily, 4 June 2009. <www.sciencedaily.com/releases/2009/06/090603113712.htm>.
United States Geological Survey. (2009, June 4). Estrogen Linked To Lowered Immunity In Fish. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2009/06/090603113712.htm
United States Geological Survey. "Estrogen Linked To Lowered Immunity In Fish." ScienceDaily. www.sciencedaily.com/releases/2009/06/090603113712.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dog Flu Spreading in Midwestern States

Dog Flu Spreading in Midwestern States

AP (Apr. 17, 2015) Dog flu is spreading in several Midwestern states. Dog daycare centers and veterinary offices are taking precautions. (April 17) Video provided by AP
Powered by NewsLook.com
Raw: Rare Whale Spotted in Gulf of Mexico

Raw: Rare Whale Spotted in Gulf of Mexico

AP (Apr. 17, 2015) Researchers from the E/V Nautilus had quite a surprise Tuesday, when a curious sperm whale swam around their remotely operated vehicle in the Gulf of Mexico. Cameras captured the encounter. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins