Featured Research

from universities, journals, and other organizations

Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease?

Date:
June 12, 2009
Source:
Journal Of Psychotherapy And Psychosomatics
Summary:
This study extends the existing literature by finding a strong association between low omega--3 fatty acids and depression in outpatients with stable coronary heart disease, a population distinct from sicker, hospitalized patients with acute coronary syndrome.

Depression is an established risk factor for the development of coronary heart disease (CHD) in healthy patients and for adverse cardiovascular outcomes in patients with existing CHD. Dietary factors resulting in lower levels of omega–3 fatty acids not only increase CHD risk, but may also be involved in the pathophysiology of depression.

The investigators measured red blood cell levels of two omega–3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and assessed depressive symptoms in a cross-sectional study of 987 adults with CHD. Omega –3 fatty acids were blindly measured in fasting venous blood samples using capillary gas chromatography to measure the fatty acid composition of red blood cell membranes. Red blood cell levels of EPA and DHA are presented as a percentage composition of total fatty acid methyl esters.

The investigators assessed current depression using the 9-item Patient Health Questionnaire. They evaluated the association between omega –3 fatty acid levels and depressive symptoms as continuous variables using linear regression.

The investigators also examined the association of omega–3 fatty acid tertiles with depression as a dichotomous variable using X2 analysis and logistic regression. All statistical tests were two-sided, and p<0.05 was considered statistically significant. The prevalence of depression ranged from 23% in participants in the lowest tertile of omega –3 fatty acids (< 3.1% of total blood fatty acids) to 13% in participants in the highest tertile ( >4.3% of total blood fatty acids; p for trend = 0.004). Each unit decrease in EPA + DHA was inversely associated with depressive symptoms as a continuous variable, and these associations persisted after adjustment for age, sex and race. Similarly, each SD decrease in EPA + DHA was associated with significantly greater odds of depression as a dichotomous variable (Patient Health Questionnaire score >10).

However, in both analyses, omega–3 fatty acid levels were no longer associated with depression after adjustment for education and household income level. This study extends this existing literature by finding a strong association between low omega–3 fatty acids and depression in outpatients with stable CHD, a population distinct from sicker, hospitalized patients with acute coronary syndrome. In addition, the investigators examined the role of several important potential confounders and measured erythrocyte membrane levels of fatty acids rather than using less accurate serum measurements or dietary questionnaires. However, the cross-sectional nature of this study precluded the investigators from making any definitive comments on causality.

Additionally, the cohort participants were mostly older, urban men and thus are not entirely reflective of the general population. To better understand the potential efficacy of omega –3 fatty acid supplementation for improving depressive symptoms in patients with CHD, future studies should carefully consider the role of socioeconomic status (SES) in this association.


Story Source:

The above story is based on materials provided by Journal Of Psychotherapy And Psychosomatics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ali et al. Association between Omega-3 Fatty Acids and Depressive Symptoms among Patients with Established Coronary Artery Disease: Data from the Heart and Soul Study. Psychotherapy and Psychosomatics, 2009; 78 (2): 125 DOI: 10.1159/000203118

Cite This Page:

Journal Of Psychotherapy And Psychosomatics. "Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease?." ScienceDaily. ScienceDaily, 12 June 2009. <www.sciencedaily.com/releases/2009/06/090609073022.htm>.
Journal Of Psychotherapy And Psychosomatics. (2009, June 12). Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease?. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/06/090609073022.htm
Journal Of Psychotherapy And Psychosomatics. "Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease?." ScienceDaily. www.sciencedaily.com/releases/2009/06/090609073022.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins