Featured Research

from universities, journals, and other organizations

'Designer Molecules' Being Developed To Fight Disease

Date:
June 13, 2009
Source:
University of Leicester
Summary:
Researchers are developing a new way to make protein based drugs with potential applications in stroke, vascular inflammation, blood vessel formation, regenerative medicine and tissue engineering.

Researchers in the Department of Cardiovascular Sciences at the University of Leicester are developing a new way to make protein based drugs with potential applications in stroke, vascular inflammation, blood vessel formation, regenerative medicine and tissue engineering.

Related Articles


The research carried out by Shikha Sharma in Dr Nick Brindle's group in Department of Cardiovascular Sciences aims to allow researchers to rapidly make 'designer proteins' that can bind to disease causing molecules in the body.

Shikha Sharma said "There are millions of different proteins that are involved in carrying out numerous functions in the human body. Over time each protein has evolved to optimise its function. Disease could result if any of these fail to perform efficiently."

"By generating designer proteins in test tubes, we can produce molecules that have specific actions to control processes in the body. These proteins can be used to make drugs as a treatment for heart disease and cancer."

She said: "Whilst most drugs in current use are synthetic, these designer molecules are developed from natural proteins and are likely to have fewer side effects. Proteins perform a well defined but complex set of function in the body and protein therapeutic drugs can perform better when compared to some synthetic small molecule drugs that may have unwanted interactions within the body."

"Current methods to generate protein therapeutic are cumbersome and time consuming. At the University of Leicester, we have developed a novel method to revolutionise the way in which we produce these designer protein drugs. In principle this method mimics natural evolution to make new proteins but over a shorter timescale. Instead of taking millions of years, we can create new proteins in just a few weeks."

She said: "The fact that this new method utilizes a similar mechanism by which antibodies are generated, suggests the output from this method will be as robust and dynamic as the wide range of antibodies produced in our bodies to fight the rapidly evolving viruses in the environment."

Dr Brindle said: "Shikha has made great progress towards this new method, which holds the promise of new better drugs for a wide range of human and animal disease."

In addition to medicine, the method holds promise for a wide range of applications in the chemical, pharmaceutical, and agricultural industries, such as generating protein molecules to prevent uptake of toxins in crops or protein molecules for detection of environmental pollutants.

Shikha Sharma will be presenting her research at the Festival of Postgraduate Research which is taking place on June 25 at the University of Leicester.


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Cite This Page:

University of Leicester. "'Designer Molecules' Being Developed To Fight Disease." ScienceDaily. ScienceDaily, 13 June 2009. <www.sciencedaily.com/releases/2009/06/090611192132.htm>.
University of Leicester. (2009, June 13). 'Designer Molecules' Being Developed To Fight Disease. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2009/06/090611192132.htm
University of Leicester. "'Designer Molecules' Being Developed To Fight Disease." ScienceDaily. www.sciencedaily.com/releases/2009/06/090611192132.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
This Is What It's Like To Date A Med Student

This Is What It's Like To Date A Med Student

BuzzFeed (Jan. 23, 2015) Dating is now speed-dating... or studying. Video provided by BuzzFeed
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins