Featured Research

from universities, journals, and other organizations

Single Gene Found To Control Growth Of Some Cancers

Date:
June 17, 2009
Source:
Louisiana State University Health Sciences Center
Summary:
A single gene can control growth in cancers related to the Epstein-Barr virus and that existing therapeutics can inactivate it, according to new research.

Research led by Ashok Aiyar, PhD, Associate Professor of Microbiology at LSU Health Sciences Center New Orleans, showing that a single gene can control growth in cancers related to the Epstein-Barr virus and that existing therapeutics can inactivate it, will be published in the June 12, 2009 online issue of PLoS Pathogens.

The Epstein-Barr virus (EBV) is closely associated with many human cancers such as Burkitt's lymphoma, Hodgkin's lymphoma, AIDS-related lymphomas, post-transplant lymphoproliferative disease, cancers of the nose and throat, and stomach cancer. In many of these malignancies, proteins made by EBV are necessary for tumor cells to grow indiscriminately. This is especially true of AIDS-related lymphomas and post-transplant lymphoproliferative disease, which are serious complications of AIDS and transplant surgery. These cancers are responsible for thousands of deaths each year in the United States.

The LSUHSC research team, which also includes Kenneth Johnston, PhD, Professor of Microbiology, and Timothy Foster, PhD, Assistant Professor of Microbiology and faculty of the LSUHSC Gene Therapy Program, investigated a small region of a certain Epstein-Barr virus protein called EBNA1, to determine the role it plays in the activation of the EBV genes responsible for the indiscriminate growth of tumor cells in these cancers. Their research shows that EBNA1 is controlled by oxidative stress (pathologic changes in response to excessive levels of free radicals) within the EBV-infected cells. Varying levels of oxidative stress change EBNA1's ability to activate EBV genes responsible for indiscriminate tumor cell growth.

"We have shown that in vitro, existing therapeutics such as Vitamin K that can change oxidative stress within cells, inactivate EBNA1," notes Dr. Aiyar, who is also a member of the faculty of the LSUHSC Stanley S. Scott Cancer Center. "As a consequence, EBV genes required for proliferation are no longer expressed, and malignantly transformed cells stop proliferating."

The research was funded by grants from the National Cancer Institute, the Louisiana Cancer Research Consortium, and the Department of Microbiology, Immunology, and Parasitology at LSU Health Sciences Center New Orleans School of Medicine.

"It is our hope that this research will lead to new ways of controlling EBV-associated diseases in humans," concludes Dr. Aiyar.


Story Source:

The above story is based on materials provided by Louisiana State University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Louisiana State University Health Sciences Center. "Single Gene Found To Control Growth Of Some Cancers." ScienceDaily. ScienceDaily, 17 June 2009. <www.sciencedaily.com/releases/2009/06/090612092739.htm>.
Louisiana State University Health Sciences Center. (2009, June 17). Single Gene Found To Control Growth Of Some Cancers. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/06/090612092739.htm
Louisiana State University Health Sciences Center. "Single Gene Found To Control Growth Of Some Cancers." ScienceDaily. www.sciencedaily.com/releases/2009/06/090612092739.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins