Featured Research

from universities, journals, and other organizations

Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein

Date:
June 29, 2009
Source:
Public Library of Science
Summary:
Scientists can now describe the highest resolution three-dimensional structure yet of a membrane protein, in this case of a protein channel known as an aquaporin that regulates water flow into and out of yeast cells.

X-ray structure of Aqy1 at 1.15 resolution.
Credit: Fischer et al. PLoS Biol, DOI: 10.1371/journal.pbio.1000130

Water is a crucial ingredient for life, but its level inside cells must be carefully regulated to maintain proper cell shape and size. Scientists from the University of Gothenburg describe the highest resolution three-dimensional structure yet of a membrane protein, in this case of a protein channel known as an aquaporin that regulates water flow into and out of yeast cells. Virtually all living organisms use aquaporins to regulate water flow between the cell and its surroundings.

Related Articles


The unique high resolution of the x-ray crystallography data presented here by Karin Lindkvist, Richard Neutze, and colleagues from Germany and Sweden has enabled the scientists to visualise the role of a previously mysterious region of the yeast aquaporin molecule – a long "tail" (or amino-terminal extension) that these authors now show regulates water flow by regulating the opening and closing of the wa ter channel.

"Our study shows that the amino-terminal extensions in yeast act as a gate that can be opened and closed depending on how much water the cell must release or absorb. Computer simulations and biological experiments suggest that the channel is regulated with a combination of mechanical regulation and phosphorylation," says Karin Lindkvist.

Previously published research from studies in mice has shown that inhibiting the function of aquaporins can dramatically reduce the spread and growth of tumours. These authors hope that research such as theirs into the regulation of aquaporins in simpler organisms such as yeast will provide insight into aquaporin function in higher organisms. Potentially, "The structure of the yeast aquaporin that we have determined can be used to create inhibitors for human aquaporins, and this may in the long term lead to drugs that slow the growth of a cancer tumour," says Karin Lindkvist, senior author on the paper.

This work was supported by grants from the European Commission (The Marie Curie Research Training Network of Aqua(glycero)porins), the Swedish Science Research Council (VR), The Swedish Strategic Research Foundation (SSF), the University of Gothenburg Quantitative Biology Platform, and the EU Integrated projects E-MEP and EDICT. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fischer G, Kosinska-Eriksson U, Aponte-Santamarıa C, Palmgren M, Geijer C, et al. Crystal Structure of a Yeast Aquaporin at 1.15 A Reveals a Novel Gating Mechanism. PLoS Biol, 7(6): e1000130 DOI: 10.1371/journal.pbio.1000130

Cite This Page:

Public Library of Science. "Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein." ScienceDaily. ScienceDaily, 29 June 2009. <www.sciencedaily.com/releases/2009/06/090615203100.htm>.
Public Library of Science. (2009, June 29). Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/06/090615203100.htm
Public Library of Science. "Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein." ScienceDaily. www.sciencedaily.com/releases/2009/06/090615203100.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins