Featured Research

from universities, journals, and other organizations

Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein

Date:
June 29, 2009
Source:
Public Library of Science
Summary:
Scientists can now describe the highest resolution three-dimensional structure yet of a membrane protein, in this case of a protein channel known as an aquaporin that regulates water flow into and out of yeast cells.

X-ray structure of Aqy1 at 1.15 resolution.
Credit: Fischer et al. PLoS Biol, DOI: 10.1371/journal.pbio.1000130

Water is a crucial ingredient for life, but its level inside cells must be carefully regulated to maintain proper cell shape and size. Scientists from the University of Gothenburg describe the highest resolution three-dimensional structure yet of a membrane protein, in this case of a protein channel known as an aquaporin that regulates water flow into and out of yeast cells. Virtually all living organisms use aquaporins to regulate water flow between the cell and its surroundings.

Related Articles


The unique high resolution of the x-ray crystallography data presented here by Karin Lindkvist, Richard Neutze, and colleagues from Germany and Sweden has enabled the scientists to visualise the role of a previously mysterious region of the yeast aquaporin molecule – a long "tail" (or amino-terminal extension) that these authors now show regulates water flow by regulating the opening and closing of the wa ter channel.

"Our study shows that the amino-terminal extensions in yeast act as a gate that can be opened and closed depending on how much water the cell must release or absorb. Computer simulations and biological experiments suggest that the channel is regulated with a combination of mechanical regulation and phosphorylation," says Karin Lindkvist.

Previously published research from studies in mice has shown that inhibiting the function of aquaporins can dramatically reduce the spread and growth of tumours. These authors hope that research such as theirs into the regulation of aquaporins in simpler organisms such as yeast will provide insight into aquaporin function in higher organisms. Potentially, "The structure of the yeast aquaporin that we have determined can be used to create inhibitors for human aquaporins, and this may in the long term lead to drugs that slow the growth of a cancer tumour," says Karin Lindkvist, senior author on the paper.

This work was supported by grants from the European Commission (The Marie Curie Research Training Network of Aqua(glycero)porins), the Swedish Science Research Council (VR), The Swedish Strategic Research Foundation (SSF), the University of Gothenburg Quantitative Biology Platform, and the EU Integrated projects E-MEP and EDICT. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fischer G, Kosinska-Eriksson U, Aponte-Santamarıa C, Palmgren M, Geijer C, et al. Crystal Structure of a Yeast Aquaporin at 1.15 A Reveals a Novel Gating Mechanism. PLoS Biol, 7(6): e1000130 DOI: 10.1371/journal.pbio.1000130

Cite This Page:

Public Library of Science. "Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein." ScienceDaily. ScienceDaily, 29 June 2009. <www.sciencedaily.com/releases/2009/06/090615203100.htm>.
Public Library of Science. (2009, June 29). Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/06/090615203100.htm
Public Library of Science. "Yeast: Highest Resolution Three-dimensional Structure Yet Of A Membrane Protein." ScienceDaily. www.sciencedaily.com/releases/2009/06/090615203100.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins