Featured Research

from universities, journals, and other organizations

Histamine Affects Alcohol-related Behavior

Date:
June 29, 2009
Source:
Academy of Finland
Summary:
The histamine-3 receptor is important in terms of alcohol-related behavior, and a drug affecting that receptor may have qualities that alter alcohol-related behavior.

The histamine-3 receptor is important in terms of alcohol-related behaviour, and a drug affecting that receptor may have qualities that alter alcohol-related behaviour. This appears in the study headed by Pertti Panula entitled “Tuberomamillary nucleus neurons, histamine and H3 receptor in hypothalamic regulation of alcohol addiction” which is part of the Substance Use and Addictions research programme of the Academy of Finland.

“Whether these histamine-3 receptor drugs help in the treatment of human alcoholism will probably be clear when the results of the currently ongoing clinical trials become public. The drugs are currently being tested for the treatment of conditions such as observation disorders, sleep disorders and narcolepsy,” says Professor Panula.

In addition to the well-known dopamine and serotonin, neurotransmitters that are important to the functioning of the brain also include histamine, which is better known for the regulation of allergies and stomach functioning. The histamine system of the brain is important in the regulation of the sleep-waking rhythm. There is also an extensive histamine system in the human brain.

In Professor Panula’s previous studies it was observed that the brain histamine content of a rat population that liked to drink alcohol was higher compared with other rat populations. The alcohol consumption of these rats was reduced by giving the rats an agent that blocks the new histamine-3 receptor that was discovered in the studies. These studies showed that the histamine system of the brain is part of the mechanism that regulates alcohol consumption.

The latest studies used mice in whose brain the histamine producing enzyme and, consequently, histamine is completely lacking. These mice did not become livelier after receiving alcohol as did the mice in the control group. On the other hand, the rewarding pleasure effect of alcohol was stronger in the mice lacking histamine compared with normal mice.

It was also observed in the study that the effects of alcohol that cause liveliness and pleasure changed noticeably when a histamine-3 receptor blocker was used. The results suggest that, in addition to the use of alcohol, transmitter histamine also contributes to the transmission of the stimulating and pleasing effect of alcohol in the brain.


Story Source:

The above story is based on materials provided by Academy of Finland. Note: Materials may be edited for content and length.


Cite This Page:

Academy of Finland. "Histamine Affects Alcohol-related Behavior." ScienceDaily. ScienceDaily, 29 June 2009. <www.sciencedaily.com/releases/2009/06/090616080147.htm>.
Academy of Finland. (2009, June 29). Histamine Affects Alcohol-related Behavior. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/06/090616080147.htm
Academy of Finland. "Histamine Affects Alcohol-related Behavior." ScienceDaily. www.sciencedaily.com/releases/2009/06/090616080147.htm (accessed April 23, 2014).

Share This



More Mind & Brain News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
Do We Get Nicer With Age?

Do We Get Nicer With Age?

Newsy (Apr. 22, 2014) A recent report claims personality can change over time as we age, and usually that means becoming nicer and more emotionally stable. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins