Featured Research

from universities, journals, and other organizations

Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity

Date:
June 24, 2009
Source:
Journal of Clinical Investigation
Summary:
Why the immune system of a pregnant woman does not attack her developing fetus is one of most remarkable features of pregnancy, and several underlying mechanisms have been described. Scientists have now identified a new mechanism to explain why the mouse maternal immune system does not attack the fetuses.

Why the immune system of a pregnant woman does not attack her developing fetus is one of most remarkable features of pregnancy, and several underlying mechanisms have been described. However, Adrian Erlebacher and colleagues, at the New York University School of Medicine, New York, have now identified a new mechanism to explain why the mouse maternal immune system does not attack the fetuses.

Related Articles


Once an embryo implants into the wall of the uterus, a cellular structure known as the decidua forms around the embryo and placenta. In the study, the formation of the decidua was found to prevent immune sentinel cells known as DCs from leaving the maternal/fetal interface and traveling to the local lymph nodes to activate an immune response toward the fetus.

The authors therefore suggest that impaired formation or function of the human decidua might allow DCs to leave the decidua to initiate an aggressive immune response toward the fetus, something that might contribute to poor pregnancy outcomes.

In an accompanying commentary, Bali Pulendran, at Emory Vaccine Center at Yerkes National Primate Research Center, Atlanta, discusses how this new research affects current thinking about avoiding immune surveillance at the maternal/fetal interface.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mary K. Collins, Chin-Siean Tay, and Adrian Erlebacher. Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice. Journal of Clinical Investigation, June 22, 2009

Cite This Page:

Journal of Clinical Investigation. "Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity." ScienceDaily. ScienceDaily, 24 June 2009. <www.sciencedaily.com/releases/2009/06/090622171403.htm>.
Journal of Clinical Investigation. (2009, June 24). Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2009/06/090622171403.htm
Journal of Clinical Investigation. "Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity." ScienceDaily. www.sciencedaily.com/releases/2009/06/090622171403.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins