Featured Research

from universities, journals, and other organizations

New Insight On Therapy For Devastating Parasitic Disease

Date:
July 2, 2009
Source:
University of Minnesota
Summary:
Researchers have discovered an important new insight into how a commonly prescribed drug may work to treat those infected by a parasitic flatworm.

University of Minnesota Medical School researchers have discovered an important new insight into how a commonly prescribed drug may work to treat those infected by a parasitic flatworm.

Related Articles


The Schistosomasis parasite infects about 200 million people in tropical areas worldwide and is endemic in more than 70 countries, where people become infected simply by bathing, drinking, or cooking water contaminated with the flatworm. Although not immediately deadly, left untreated, the disease can permanently damage the lungs, kidney, liver, and intestines and ultimately lead to death.

A drug called praziquantel has been used as the main treatment for Schistosomiasis for several decades, but surprisingly, scientists have never understood how this drug works to kill the parasitic worms that cause this disease. Deciphering how this drug works is important because scientists could design new drugs that work in similar ways should the parasites develop resistance to praziquantel.

While working in a different species of flatworm widely used to study the basic principles of regenerative biology, researchers in the Pharmacology Department discovered that praziquantel caused a simple, striking effect: the drug subverts normal regeneration to produce two-headed organisms. This simple observation was then used to screen for genes required to control this effect, leading to the identification of molecules that control the effects of praziquantel within a flatworm model.

"Our discovery of this new biological activity of praziquantel provides a foundation for defining the relevant in vivo targets of a very important clinical drug," said Jonathan Marchant, M.A. Ph.D., principal investigator of the study. "Using drugs to make organisms grow two brains may seem bizarre, but the knowledge we gained illustrates the importance of basic scientific research."

The study is published in the June 23 issue of PLoS Neglected Tropical Diseases.

"Discoveries by researchers working in diverse animal models not linked with disease frequently provide insight into long-standing clinical problems," Marchant said. "Basic science feeds into the therapeutic pipeline in unpredictable ways and it is important to foster such diversity."

This work was funded by the National Science Foundation.


Story Source:

The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University of Minnesota. "New Insight On Therapy For Devastating Parasitic Disease." ScienceDaily. ScienceDaily, 2 July 2009. <www.sciencedaily.com/releases/2009/06/090623112112.htm>.
University of Minnesota. (2009, July 2). New Insight On Therapy For Devastating Parasitic Disease. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/06/090623112112.htm
University of Minnesota. "New Insight On Therapy For Devastating Parasitic Disease." ScienceDaily. www.sciencedaily.com/releases/2009/06/090623112112.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins