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Blood Flow In Alzheimer's Disease

Date:
June 29, 2009
Source:
American Journal of Pathology
Summary:
Scientists have discovered that endothelin converting enzyme-2 (ECE-2) may cause the decrease in cerebral blood flow seen in Alzheimer's disease. 
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Dr. Jennifer C Palmer and colleagues at the University of Bristol have discovered that endothelin converting enzyme-2 (ECE-2) may cause the decrease in cerebral blood flow seen in Alzheimer's disease. 

Alzheimer's disease is the most common form of dementia. Aβ peptide, which accumulates in the brain of Alzheimer's disease patients, is thought to lead to tightening of the blood vessels and reduction of cerebral blood flood. ECE-2 may contribute to these symptoms by converting an inactive precursor to endothelin-1, which constricts blood vessels.

To determine if ECE-2 affects cerebral blood flow in Alzheimer's disease, Palmer et al examined the expression of ECE-2. They found that ECE-2 levels were elevated in patients with Alzheimer's disease and that Aβ could increase ECE-2 expression in vitro. These data indicate that ECE-2 levels are increased in response to Aβ and may cause the decrease in cerebral blood flow seen in Alzheimer's disease.

Palmer et al "suggest that [endothelin-1] receptor antagonists, already licensed for treating other diseases, could be of benefit in [Alzheimer's disease] therapies."


Story Source:

The above post is reprinted from materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Palmer JC, Baig S, Kehoe PG, Love S. Endothelin-Converting Enzyme-2 is Increased in Alzheimer's Disease. Am J Pathol, 2009, 174: 2672-2680

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American Journal of Pathology. "Blood Flow In Alzheimer's Disease." ScienceDaily. ScienceDaily, 29 June 2009. <www.sciencedaily.com/releases/2009/06/090624211135.htm>.
American Journal of Pathology. (2009, June 29). Blood Flow In Alzheimer's Disease. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/2009/06/090624211135.htm
American Journal of Pathology. "Blood Flow In Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2009/06/090624211135.htm (accessed September 1, 2015).

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