Featured Research

from universities, journals, and other organizations

Doubts Cast On Credibility Of Some Published Clinical Trials

Date:
July 3, 2009
Source:
BioMed Central
Summary:
Randomized controlled trials are considered the "gold standard" research method for assessing new medical treatments. But new research shows that the design of a remarkable 93 percent of 2235 so-called RCTs published in some Chinese medical journals during 1994 to 2005 was flawed, casting doubt on the reliability of research that is likely to influence medical decision-makers.

Randomised Controlled Trials (RCTs) are considered the 'gold standard' research method for assessing new medical treatments. But research published in BioMed Central's open access journal Trials shows that the design of a remarkable 93 percent of 2235 so-called RCTs published in some Chinese medical journals during 1994 to 2005 was flawed, casting doubt on the reliability of research that is likely to influence medical decision-makers.

Related Articles


Researchers led by Taixiang Wu of the Chinese Cochrane Centre at Sichuan University, China and Ottawa Hospital Research Institute investigated clinical trials published in China between 1994 and 2005, searching the China National Knowledge Infrastructure (CNKI) electronic database for RCTs on 20 common diseases. To determine how many of these met recognised standards for randomly allocating participants to treatment groups, trained investigators interviewed the first or co-authors of 2235 trial reports by phone.

Less than seven percent of self-described RCTs published in some Chinese medical journals meet criteria for authentic randomisation. The researchers looked at both conventional and traditional Chinese medicine trials, but there was no difference between these in terms of study authenticity rates. However, all RCTs of pre-market drug clinical trial were authentic, and RCTs conducted at hospitals affiliated with medical universities were more likely to be authentic than trials conducted at lower tier level three and level two hospitals. More than half of the trials at university-affiliated hospitals met RCT criteria, which means lower-tier hospital research is the least rigorous in design terms.

"The fact that so many non-RCTs were published as RCTs reflected that peer-review needs to be improved and a Good Practice of Peer Review, including how to identify the authenticity of the study, urgently needs to be developed," says Wu.

Misleading reporting of medical research is not unique to China. Studies labelled as RCTs are more likely to influence health policy-makers meaning falsely reported RCTs have the potential to mislead health care providers, consumers and policy-makers. The results of this study suggest authors of systematic reviews – articles that combine the results of multiple RCTs – need to be aware that RCTs in some Chinese journals may not be RCTs at all.

The approximately 1100 medical journals now active in China are rapidly increasing their output of research reports, including many identified by their authors as RCTs. But these trials present mostly positive results (they favour the treatment being investigated), which can be influenced by inadequate randomisation of patients when designing the study.

This study was funded by the Chinese Medical Board of New York.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Taixiang Wu, Youping Li, Zhaoxiang Bian, Guanjian Liu and David Moher. Randomized trials published in some Chinese journals: How many are randomized? Trials, (in press) [link]

Cite This Page:

BioMed Central. "Doubts Cast On Credibility Of Some Published Clinical Trials." ScienceDaily. ScienceDaily, 3 July 2009. <www.sciencedaily.com/releases/2009/07/090702184146.htm>.
BioMed Central. (2009, July 3). Doubts Cast On Credibility Of Some Published Clinical Trials. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/07/090702184146.htm
BioMed Central. "Doubts Cast On Credibility Of Some Published Clinical Trials." ScienceDaily. www.sciencedaily.com/releases/2009/07/090702184146.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Science & Society News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can Bitcoin Survive 2015?

Can Bitcoin Survive 2015?

Newsy (Dec. 22, 2014) Bitcoin's stock has tumbled significantly this year, but more companies now accept it, leading supporters and critics alike to weigh in on its future. Video provided by Newsy
Powered by NewsLook.com
Could Cheap Oil Help Fix U.S. Roads?

Could Cheap Oil Help Fix U.S. Roads?

Newsy (Dec. 21, 2014) As falling oil prices boost Americans' spending power, the U.S. government is also gaining flexibility from savings on oil. Video provided by Newsy
Powered by NewsLook.com
After Sony Hack, What's Next?

After Sony Hack, What's Next?

Reuters - US Online Video (Dec. 19, 2014) The hacking attack on Sony Pictures has U.S. government officials weighing their response to the cyber-attack. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Science & Society

Business & Industry

Education & Learning

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins