Featured Research

from universities, journals, and other organizations

Molecules Discovered With A Higher Selective Ability To Exterminate Cancer Cells

Date:
July 20, 2009
Source:
Andalucía Innova
Summary:
Researchers have obtained a new type of molecules which have proven -in in vitro cultivations- a high level of efficiency against cancer cells, as well as very low toxicity against the body’s normal cells.

Researchers of the Department of Pharmaceutical Chemistry of the University of Granada (UGR), led by Joaquín Campos Rosa, have obtained a new type of molecules which have proven -in in vitro cultivations- a high level of efficiency against cancer cells, as well as very low toxicity against the body's normal cells.

Related Articles


This important discovery in the cancer therapy field is the result of a Project of Excellence of the Andalusian Ministry of Innovation, Science and Enterprise in its first call, funded with 102,400 euros.

This discovery, which was made possible thanks to natural substances never used before for the treatment of tumours, is the result of modifying the chemical structure of a very used drug against cancer - 5-fluoruracile, one of the first drugs used in Oncology, by another similar substance called uracile. Uracile is a substance that is naturally present in our body, which is part of the cells' RNA. After the good results obtained with uracile, this substance was replaced by other similar molecules, but even more effective (guanine and cytosine). With them, the new molecules have been obtained, whose main feature is a higher therapeutical rate, that is, the quotient between the affectation over cancer cells and that over healthy cells. More specifically, their toxicity for the body is ten times lower than that of 5-fluoruracile.

The efficiency of the molecules obtained is related to their high capacity to induce apoptosis in cancer cells. Apoptosis is a function of the body that consists of programming the oldest cells' death, as they are no longer useful. Just like new cells are constantly born in our tissues, the oldest ones must also gradually die as they no longer carry out their function properly. Therefore apoptosis is a mechanism of defence of the body as it also takes place in those cells that are a threat due to failures in their normal activity. When the capability of a cell to carry out the apoptosis is damaged (for example due to a mutation) or if the beginning of apoptosis has been blocked (by a virus), the damaged cell can keep on splitting without any major restriction, thus giving rise to a tumour that can be carcinogen.

These good results in molecules designed by this research group of the UGR can be explained as a result of the capacity of such molecules to cause the cellular death of cancer-related cells. Therefore a new important research horizon has been opened regarding the identification of molecular mechanisms that induce apoptosis. From now on, these researchers will be focusing on genomics so as to go more deeply into the action mechanisms of these molecules in their interaction with pro-apoptotic genes, as they represent an enormous potential to be applied as drugs.


Story Source:

The above story is based on materials provided by Andalucía Innova. Note: Materials may be edited for content and length.


Cite This Page:

Andalucía Innova. "Molecules Discovered With A Higher Selective Ability To Exterminate Cancer Cells." ScienceDaily. ScienceDaily, 20 July 2009. <www.sciencedaily.com/releases/2009/07/090709072906.htm>.
Andalucía Innova. (2009, July 20). Molecules Discovered With A Higher Selective Ability To Exterminate Cancer Cells. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2009/07/090709072906.htm
Andalucía Innova. "Molecules Discovered With A Higher Selective Ability To Exterminate Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2009/07/090709072906.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) — According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) — A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins