Featured Research

from universities, journals, and other organizations

One Gene That Contributes To Breast Cancer's Aggressive Behavior Identified

Date:
July 27, 2009
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Scientists have identified a gene, known as RCP (or RAB11FIP1), that is frequently amplified and over-expressed in breast cancer, and functionally contributes to aggressive breast cancer behavior.

Aggressive forms of cancer are often driven by the abnormal over-expression of cancer-promoting genes, also known as oncogenes.

Studies at the Genome Institute of Singapore (GIS), a research institute under the Agency for Science, Technology and Research (A*STAR) of Singapore, have identified a gene, known as RCP (or RAB11FIP1), that is frequently amplified and over-expressed in breast cancer and functionally contributes to aggressive breast cancer behaviour.

The research findings are published in the July 20th online issue of Journal of Clinical Investigation.

The GIS team, led by Lance Miller, Ph.D., and Bing Lim, Ph.D., initially discovered that RCP expression was positively correlated with cancer recurrence in a population of breast cancer patients. This suggested that RCP may be required by some tumours for growth and metastatic spread to other organs.

When the researchers over-expressed RCP in non-cancerous breast cells, they found that RCP promotes migration, or cellular movement, which is a precursor to the ability of tumours to invade neighbouring tissues.

However, breast cancer cells in which RCP is over-expressed take on a more aggressive behaviour, including faster proliferation, enhanced migration/invasion and anchorage-independent growth.

The researchers also found that when the gene is silenced in breast cancer cells, the ability of the cells to form tumours and metastasize to other organs is greatly diminished.

They also found that RCP can activate the potent oncogene, Ras, which is aberrantly activated by mutation in about 15% of all human cancers.

"One objective in my laboratory is to discover new oncogenes that drive breast cancer progression so that we can devise therapeutic strategies for shutting these genes down," said Dr. Miller, now at Wake Forest University School of Medicine in North Carolina. "The involvement of RCP in breast cancer progression may have significant clinical ramifications, and we are now working towards a better understanding of its mechanism of action."


Story Source:

The above story is based on materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jinqiu Zhang et al. RCP is a novel breast cancer promoting gene with Ras activating function. Journal of Clinical Investigation, July 20, 2009

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "One Gene That Contributes To Breast Cancer's Aggressive Behavior Identified." ScienceDaily. ScienceDaily, 27 July 2009. <www.sciencedaily.com/releases/2009/07/090720190808.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2009, July 27). One Gene That Contributes To Breast Cancer's Aggressive Behavior Identified. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/07/090720190808.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "One Gene That Contributes To Breast Cancer's Aggressive Behavior Identified." ScienceDaily. www.sciencedaily.com/releases/2009/07/090720190808.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins