Featured Research

from universities, journals, and other organizations

Cytoplasmic Talk Of Retroviruses, Such As HIV, Helps Them Spread From Cell To Cell

Date:
July 29, 2009
Source:
Yale University
Summary:
Retroviruses such as HIV that are already within cells are much more easily transmitted when they are next to uninfected cells than if they are floating free in the bloodstream. Now, researchers have made movies of viral activity within cells that help explain why cell-to-cell transmission is so efficient and provide potential targets for a new generation of AIDS drugs.

Retroviruses (red) form in infected cell and are transmitted to neighboring cell. (upper right) Green proteins bind the cells.
Credit: Image courtesy of Yale University

Retroviruses such as HIV that are already within cells are much more easily transmitted when they are next to uninfected cells than if they are floating free in the bloodstream.

"Cell-to-cell transmission is a thousand times more efficient, which is why diseases such as AIDS are so successful and so deadly," said Walther Mothes, associate professor of microbial pathogenesis at the Yale School of Medicine. "And because the retroviruses are already in cells, they are out of reach of the immune system."

Now, Yale University researchers led by Mothes and Jing Jin, a postdoctoral associate in Mothes' lab, have made movies of viral activity within cells that help explain why cell-to-cell transmission is so efficient and provide potential targets for a new generation of AIDS drugs.

Using imaging technology that can track individual particles of virus in real time, the Yale team discovered that infected cells can specifically produce viruses at the point of contact between cells, they report in the July 27 edition of the open access journal PLoS Biology. Ten times more of these particles are found at these cellular poles than elsewhere at the surface of cells, the researchers report. The ability of infected cells to specifically produce viruses only at cell-cell interfaces explains how viruses spread so efficiently, they note.

The researchers also identified a possible weakness in the transmission chain. The team found that viruses express a sticky protein that docks with uninfected cells and then attracts viral assembly to these sites. If this adhesion molecule lacked a "cytoplasmic tail," then the viral particles did not assemble at the jumping off point between cells.

Mothes expects many more such targets will be identified as scientists work out the mechanics of cell-to-cell transmission.

"We are just opening the door to this whole process," Mothes said. "It is a black box, and many, many cellular factors have to be involved in making this happen. Our hope is that somewhere down the road we will have a completely new anti-viral strategy based on targeting cell-to-cell transmission."

Nathan M. Sherer was another Yale-affiliated author of the paper.

The work was funded by the National Cancer Institute and amfAR, The Foundation for AIDS Research.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jin J, Sherer NM, Heidecker G, Derse D, Mothes W. Assembly of the Murine Leukemia Virus Is Directed towards Sites of Cell%u2013Cell Contact. PLoS Biol, 7(7): e1000163 DOI: 10.1371/journal.pbio.1000163

Cite This Page:

Yale University. "Cytoplasmic Talk Of Retroviruses, Such As HIV, Helps Them Spread From Cell To Cell." ScienceDaily. ScienceDaily, 29 July 2009. <www.sciencedaily.com/releases/2009/07/090727203620.htm>.
Yale University. (2009, July 29). Cytoplasmic Talk Of Retroviruses, Such As HIV, Helps Them Spread From Cell To Cell. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/07/090727203620.htm
Yale University. "Cytoplasmic Talk Of Retroviruses, Such As HIV, Helps Them Spread From Cell To Cell." ScienceDaily. www.sciencedaily.com/releases/2009/07/090727203620.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins