Featured Research

from universities, journals, and other organizations

New Developments In Reproductive Medicine

Date:
August 31, 2009
Source:
Deutsches Aerzteblatt International
Summary:
Three out of ten women who undergo polar body diagnosis go on to have a child. The extensive technique of polar body analysis is described by researchers in reproductive medicine at Lubeck in an article in the current edition of Deutsches Artzeblatt International, in which they present three successful cases and one failure.

Three out of ten women who undergo polar body diagnosis go on to have a child. The extensive technique of polar body analysis (PBA) is described by researchers in reproductive medicine at Lübeck in an article in the current edition of Deutsches Ärtzeblatt International, in which they present three successful cases and one failure.

Related Articles


Polar bodies are by-products of normal cell division (meiosis) of an oocyte—a woman's egg cell—on its way to maturation. For people with monogenic diseases, which are caused by gene defects, polar body analysis can give an indication of whether the healthy version of the gene is present in the egg before fertilization takes place. Monogenic diseases, such as cystic fibrosis, are caused by an altera-tion of one gene; this makes them different from polygenic diseases, such as diabetes mellitus, for example, which are caused by a combination of defects in several genes.

In the cases of four women who were carriers of a monogenic disease, their own egg cells containing the intact version of the gene concerned were fertilized, allowed to develop to the embryonic stage, and then transferred into the womb. Three of the women had a successful pregnancy and gave birth to a healthy child. One woman failed to become pregnant, even after a further round of PBA fol-lowed by embryo transfer, and decided not to continue the treatment. These four cases are among nine couples tested using PBA at Lübeck by Georg Griesinger and his co-authors because of a known risk that the mother might transmit a monogenic disease.

In Germany PBA is an alternative to preimplantation diagnosis (PID), which depending on the result can lead to termination of pregnancy with all the associated psychological and physical stresses. The disadvantages of PBA are: hereditary diseases transmitted through the father cannot be diagnosed, and in the case of autosomal recessive diseases egg cells that would have resulted in the birth of healthy heterozygous carriers are discarded. In Germany, PBA for monogenic diseases is at present performed at only two centers, in Lübeck and Regensburg.


Story Source:

The above story is based on materials provided by Deutsches Aerzteblatt International. Note: Materials may be edited for content and length.


Cite This Page:

Deutsches Aerzteblatt International. "New Developments In Reproductive Medicine." ScienceDaily. ScienceDaily, 31 August 2009. <www.sciencedaily.com/releases/2009/08/090831130702.htm>.
Deutsches Aerzteblatt International. (2009, August 31). New Developments In Reproductive Medicine. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2009/08/090831130702.htm
Deutsches Aerzteblatt International. "New Developments In Reproductive Medicine." ScienceDaily. www.sciencedaily.com/releases/2009/08/090831130702.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins