Featured Research

from universities, journals, and other organizations

From Fat To Chronic Inflammation

Date:
September 2, 2009
Source:
Cell Press
Summary:
Researchers may have found a key ingredient in the recipe that leads from obesity to chronic low-grade inflammation, according to new research.

Researchers may have found a key ingredient in the recipe that leads from obesity to chronic low-grade inflammation, according to a report in the September issue of Cell Metabolism, a Cell Press publication.

Chronic inflammation within fat tissue is now recognized as a contributor to the many ill health consequences that come with obesity, from diabetes to cardiovascular disease, explains Yuichi Oike of Kumamoto University in Japan. The new discovery may therefore point to a targeted therapy designed to limit the health impact of the obesity epidemic, the researchers say.

The new culprit Oike's team identifies is a fat-derived protein called angiopoietin-like protein 2 (Angptl2). In mice, Angptl2 levels are elevated in many organs, but especially in fat tissue, they show. Those levels increase further under the oxygen-deprived conditions typically found within obese fat tissue. In humans, too, they find higher Angptl2 levels in the blood of people with higher body mass index and insulin levels.

Obese mice lacking Angptl2 show less inflammation in their fat tissue and are less insulin resistant, they report. Likewise, otherwise healthy mice made to have higher than normal Angptl2 levels in their fat tissue develop inflammation and insulin resistance.

They also showed additional details of what Angptl2 does. The protein starts an inflammatory cascade, causing blood vessels to remodel and attracting immune cells called macrophages.

The researchers conclude that Angptl2 is a key adipocyte-derived inflammatory mediator linking obesity to systemic insulin resistance and identify it as a new molecular target that could be used to improve the diagnosis and treatment of obesity and related metabolic diseases.

Oike says he thinks drugs that would act on Angptl2 not only have considerable promise, but are also likely to come with limited side effects.

"In healthy animals and people, the precise role of Angptl2 has not been clarified," he said. "However, mice in which Angptl2 was deleted genetically were born normally and showed normal growth compared to genetically normal mice. Therefore, we speculate that the possibility of the occurrence of a serious unfavorable side effect due to treatments that decrease Angptl2 expression in animals or people is low."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "From Fat To Chronic Inflammation." ScienceDaily. ScienceDaily, 2 September 2009. <www.sciencedaily.com/releases/2009/09/090901122629.htm>.
Cell Press. (2009, September 2). From Fat To Chronic Inflammation. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2009/09/090901122629.htm
Cell Press. "From Fat To Chronic Inflammation." ScienceDaily. www.sciencedaily.com/releases/2009/09/090901122629.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins