Featured Research

from universities, journals, and other organizations

From Fat To Chronic Inflammation

Date:
September 2, 2009
Source:
Cell Press
Summary:
Researchers may have found a key ingredient in the recipe that leads from obesity to chronic low-grade inflammation, according to new research.

Researchers may have found a key ingredient in the recipe that leads from obesity to chronic low-grade inflammation, according to a report in the September issue of Cell Metabolism, a Cell Press publication.

Chronic inflammation within fat tissue is now recognized as a contributor to the many ill health consequences that come with obesity, from diabetes to cardiovascular disease, explains Yuichi Oike of Kumamoto University in Japan. The new discovery may therefore point to a targeted therapy designed to limit the health impact of the obesity epidemic, the researchers say.

The new culprit Oike's team identifies is a fat-derived protein called angiopoietin-like protein 2 (Angptl2). In mice, Angptl2 levels are elevated in many organs, but especially in fat tissue, they show. Those levels increase further under the oxygen-deprived conditions typically found within obese fat tissue. In humans, too, they find higher Angptl2 levels in the blood of people with higher body mass index and insulin levels.

Obese mice lacking Angptl2 show less inflammation in their fat tissue and are less insulin resistant, they report. Likewise, otherwise healthy mice made to have higher than normal Angptl2 levels in their fat tissue develop inflammation and insulin resistance.

They also showed additional details of what Angptl2 does. The protein starts an inflammatory cascade, causing blood vessels to remodel and attracting immune cells called macrophages.

The researchers conclude that Angptl2 is a key adipocyte-derived inflammatory mediator linking obesity to systemic insulin resistance and identify it as a new molecular target that could be used to improve the diagnosis and treatment of obesity and related metabolic diseases.

Oike says he thinks drugs that would act on Angptl2 not only have considerable promise, but are also likely to come with limited side effects.

"In healthy animals and people, the precise role of Angptl2 has not been clarified," he said. "However, mice in which Angptl2 was deleted genetically were born normally and showed normal growth compared to genetically normal mice. Therefore, we speculate that the possibility of the occurrence of a serious unfavorable side effect due to treatments that decrease Angptl2 expression in animals or people is low."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "From Fat To Chronic Inflammation." ScienceDaily. ScienceDaily, 2 September 2009. <www.sciencedaily.com/releases/2009/09/090901122629.htm>.
Cell Press. (2009, September 2). From Fat To Chronic Inflammation. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2009/09/090901122629.htm
Cell Press. "From Fat To Chronic Inflammation." ScienceDaily. www.sciencedaily.com/releases/2009/09/090901122629.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins