Featured Research

from universities, journals, and other organizations

Oxidized Form Of A Common Vitamin May Bring Relief For Ulcerative Colitis

Date:
October 1, 2009
Source:
Federation of American Societies for Experimental Biology
Summary:
Here's another reason why you should take your vitamins. A new research report suggests that retinoic acid, the oxidized form of vitamin A, could be a beneficial treatment for people suffering from ulcerative colitis and other irritable bowel diseases. Specifically they found that retinoic acid helps suppress out-of-control inflammation, which is a hallmark of active ulcerative colitis.

Here's another reason why you should take your vitamins. A new research report appearing in the October 2009 print issue of the Journal of Leukocyte Biology suggests that retinoic acid, the oxidized form of vitamin A, could be a beneficial treatment for people suffering from ulcerative colitis and other irritable bowel diseases. Specifically they found that retinoic acid helps suppress out-of-control inflammation, which is a hallmark of active ulcerative colitis.

"Pharmaceutical strategies based on this research may offer a promising alternative to our current approaches of managing immune diseases including, IBD, arthritis, multiple sclerosis, and so on," Aiping Bai, a researcher involved in the work from Nanchang University in Nanchang City, China.

To make this discovery, Bai and colleagues conducted in vitro studies with human tissue and in vivo studies in mice. Both studies ultimately found that treatment with retinoic acid reduced the inflammation in the colon by increasing the expression of FOXP3, a gene involved with immune system responses, as well as decreasing the expression of IL-17, a cytokine believed to cause inflammation. Because many experts believe that IL-17 directly relates to the uncontrolled inflammation seen in ulcerative colitis and irritable bowel disease, the discovery that retinoic acid reduces IL-17's ability to cause inflammation could accelerate the development of treatments for these chronic diseases.

"Runaway inflammation is serious problem, no matter where it occurs in the body, but in many instances, the root cause is a mystery," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This research helps scientists better understand what causes and controls inflammation in the colon, which in turn, helps lay the groundwork for new classes of drugs to treat this devastating condition."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bai et al. All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis. Journal of Leukocyte Biology, 2009; 86 (4): 959 DOI: 10.1189/jlb.0109006

Cite This Page:

Federation of American Societies for Experimental Biology. "Oxidized Form Of A Common Vitamin May Bring Relief For Ulcerative Colitis." ScienceDaily. ScienceDaily, 1 October 2009. <www.sciencedaily.com/releases/2009/10/091001091755.htm>.
Federation of American Societies for Experimental Biology. (2009, October 1). Oxidized Form Of A Common Vitamin May Bring Relief For Ulcerative Colitis. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2009/10/091001091755.htm
Federation of American Societies for Experimental Biology. "Oxidized Form Of A Common Vitamin May Bring Relief For Ulcerative Colitis." ScienceDaily. www.sciencedaily.com/releases/2009/10/091001091755.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins