Featured Research

from universities, journals, and other organizations

Important Defence Against Stomach Ulcer Bacterium Identified

Date:
October 13, 2009
Source:
University of Gothenburg
Summary:
A special protein in the lining of the stomach has been shown to be an important part of the body’s defence against the stomach ulcer bacterium Helicobacter pylori in a new study from researchers in Sweden. The discovery may explain why the bacterium makes some people more ill than others.

A special protein in the lining of the stomach has been shown to be an important part of the body’s defence against the stomach ulcer bacterium Helicobacter pylori in a new study from the Sahlgrenska Academy at the University of Gothenburg. The discovery may explain why the bacterium makes some people more ill than others.

Related Articles


The study was conducted in collaboration with researchers at universities in Brisbane and Melbourne and has been published in the scientific journal PLoS Pathogens.

“Half of all people carry Helicobacter pylori in their bodies,” says Sara Lindén from the Sahlgrenska Academy, one of the researchers behind the study. “Many don’t even notice that they have the bacterium, but some develop stomach ulcers, and in some cases the inflammation leads to stomach cancer. Our discovery may partially explain why the bacterium affects people so differently.”

The research team has shown that a protein called MUC1 found in the lining of the stomach is important for the body’s defence against the bacterium. Greatly magnified, MUC1 looks like a tree growing out of low bushes on the surface of the stomach. As MUC1 is taller than the other structures on the cell surface, Helicobacter pylori readily becomes attached to the protein and then rarely gets to infect the cell.

“You could say that MUC1 acts as a decoy which prevents the bacterium from coming into close contact with the cell surface,” says Lindén. “Genetic variations between people mean that our MUC1 molecules vary in length, and this may be part of the reason why Helicobacter pylori makes some people more ill than others.”

The Research team of Sara Lindén is located at the Sahlgrenska Academy’s strategic research centre MIVAC (Mucosal Immunobiology and Vaccine Center). Researchers at the centre are developing new ways of treating diseases that affect the mucus membranes.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy HJ Florin, Philip Sutton and Michael A McGuckin. MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy. PLoS Pathogens, 2009; 5 (10): e1000617 DOI: 10.1371/journal.ppat.1000617

Cite This Page:

University of Gothenburg. "Important Defence Against Stomach Ulcer Bacterium Identified." ScienceDaily. ScienceDaily, 13 October 2009. <www.sciencedaily.com/releases/2009/10/091012095531.htm>.
University of Gothenburg. (2009, October 13). Important Defence Against Stomach Ulcer Bacterium Identified. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/10/091012095531.htm
University of Gothenburg. "Important Defence Against Stomach Ulcer Bacterium Identified." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012095531.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins