Featured Research

from universities, journals, and other organizations

Important Defence Against Stomach Ulcer Bacterium Identified

Date:
October 13, 2009
Source:
University of Gothenburg
Summary:
A special protein in the lining of the stomach has been shown to be an important part of the body’s defence against the stomach ulcer bacterium Helicobacter pylori in a new study from researchers in Sweden. The discovery may explain why the bacterium makes some people more ill than others.

A special protein in the lining of the stomach has been shown to be an important part of the body’s defence against the stomach ulcer bacterium Helicobacter pylori in a new study from the Sahlgrenska Academy at the University of Gothenburg. The discovery may explain why the bacterium makes some people more ill than others.

The study was conducted in collaboration with researchers at universities in Brisbane and Melbourne and has been published in the scientific journal PLoS Pathogens.

“Half of all people carry Helicobacter pylori in their bodies,” says Sara Lindén from the Sahlgrenska Academy, one of the researchers behind the study. “Many don’t even notice that they have the bacterium, but some develop stomach ulcers, and in some cases the inflammation leads to stomach cancer. Our discovery may partially explain why the bacterium affects people so differently.”

The research team has shown that a protein called MUC1 found in the lining of the stomach is important for the body’s defence against the bacterium. Greatly magnified, MUC1 looks like a tree growing out of low bushes on the surface of the stomach. As MUC1 is taller than the other structures on the cell surface, Helicobacter pylori readily becomes attached to the protein and then rarely gets to infect the cell.

“You could say that MUC1 acts as a decoy which prevents the bacterium from coming into close contact with the cell surface,” says Lindén. “Genetic variations between people mean that our MUC1 molecules vary in length, and this may be part of the reason why Helicobacter pylori makes some people more ill than others.”

The Research team of Sara Lindén is located at the Sahlgrenska Academy’s strategic research centre MIVAC (Mucosal Immunobiology and Vaccine Center). Researchers at the centre are developing new ways of treating diseases that affect the mucus membranes.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy HJ Florin, Philip Sutton and Michael A McGuckin. MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy. PLoS Pathogens, 2009; 5 (10): e1000617 DOI: 10.1371/journal.ppat.1000617

Cite This Page:

University of Gothenburg. "Important Defence Against Stomach Ulcer Bacterium Identified." ScienceDaily. ScienceDaily, 13 October 2009. <www.sciencedaily.com/releases/2009/10/091012095531.htm>.
University of Gothenburg. (2009, October 13). Important Defence Against Stomach Ulcer Bacterium Identified. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/10/091012095531.htm
University of Gothenburg. "Important Defence Against Stomach Ulcer Bacterium Identified." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012095531.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins