Featured Research

from universities, journals, and other organizations

Milestone Discovery In Cell Behaviors

Date:
October 18, 2009
Source:
Monash University
Summary:
Molecular scientists have discovered a new, fast mechanism by which cells communicate change -- for example their location during spreading of a cancer in the human body -- to adjacent cells. The discovery sheds new light on cell behaviour and could lead to the development on new drugs to combat diseases such as cancer, rheumatoid arthritis and Alzheimer's disease.

A team of international molecular scientists, led by a Monash University researcher has discovered a new, fast mechanism by which cells communicate change – for example their location during spreading of a cancer in the human body – to adjacent cells.

Related Articles


The discovery sheds new light on cell behaviour and could lead to the development on new drugs to combat diseases such as cancer, rheumatoid arthritis and Alzheimer's disease.

The team led by Monash University Associate Professor Martin Lackmann found that for one particular communicator between cells, an enzyme known as A-Disintegrin-And-Metalloprotease 10 (ADAM10), a change in the shape of its contender (communication partner) will start the communication process.

Scientists are interested in ADAM10 -- and the proteins that are split by this protease -- because it is critical in cellular mechanisms that underlie several major diseases.

"This communication process between cells forms the basis for the way in which certain diseases progress. This discovery will change how we understand cell behaviour and change how we consider the design of therapeutic drugs in this area" Associate Professor Lackmann said.

"This new concept in understanding of how cells communicate identifies a process that is much simpler than previously thought and which will profoundly impact the direction of future biomedical research in this area," he said.

"The research team found that instead of using complex signalling pathways, this communication system is really very direct and simple. In this case it is a transient switch in the overall shape of the contending cell surface receptor itself which activates the ADAM10 protease to communicate this change and its functional consequences to a neighbouring cell.

"The discovery of this switch opens new avenues for the development of drugs that recognise this changed shape and prevent the signalling to other cells, thus slowing or even halting the spread of disease.

The discovery was made using fluorescence and electron microscopy techniques, which allowed the observation of intact cells at single molecule resolution the changes in the shape of the cell surface receptor that occur during cell-to-cell communication.

The discovery was published online in the open-access journal PLoS Biology.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Cite This Page:

Monash University. "Milestone Discovery In Cell Behaviors." ScienceDaily. ScienceDaily, 18 October 2009. <www.sciencedaily.com/releases/2009/10/091014102205.htm>.
Monash University. (2009, October 18). Milestone Discovery In Cell Behaviors. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/10/091014102205.htm
Monash University. "Milestone Discovery In Cell Behaviors." ScienceDaily. www.sciencedaily.com/releases/2009/10/091014102205.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bionic Ants Could Be Tomorrow's Factory Workers

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com
Captive-Born Panda Triplets Are Eight Months Old

Captive-Born Panda Triplets Are Eight Months Old

Reuters - Light News Video Online (Mar. 30, 2015) The world&apos;s only surviving captivity-born panda triplets turn eight months old, according to China’s state media. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Lions Make Surprise Comeback in Gabon

Lions Make Surprise Comeback in Gabon

AFP (Mar. 30, 2015) Lions have made a comeback in southeast Gabon, after disappearing for years, according to live footage from US wildlife organisation Panthera. Duration: 00:32 Video provided by AFP
Powered by NewsLook.com
Ancient Egyptian Beer Making Vessels Discovered in Israel

Ancient Egyptian Beer Making Vessels Discovered in Israel

AFP (Mar. 30, 2015) Fragments of pottery used by Egyptians to make beer and dating back 5,000 years have been discovered on a building site in Tel Aviv, the Israeli Antiquities Authority said on Sunday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins