Featured Research

from universities, journals, and other organizations

Milestone Discovery In Cell Behaviors

Date:
October 18, 2009
Source:
Monash University
Summary:
Molecular scientists have discovered a new, fast mechanism by which cells communicate change -- for example their location during spreading of a cancer in the human body -- to adjacent cells. The discovery sheds new light on cell behaviour and could lead to the development on new drugs to combat diseases such as cancer, rheumatoid arthritis and Alzheimer's disease.

A team of international molecular scientists, led by a Monash University researcher has discovered a new, fast mechanism by which cells communicate change – for example their location during spreading of a cancer in the human body – to adjacent cells.

The discovery sheds new light on cell behaviour and could lead to the development on new drugs to combat diseases such as cancer, rheumatoid arthritis and Alzheimer's disease.

The team led by Monash University Associate Professor Martin Lackmann found that for one particular communicator between cells, an enzyme known as A-Disintegrin-And-Metalloprotease 10 (ADAM10), a change in the shape of its contender (communication partner) will start the communication process.

Scientists are interested in ADAM10 -- and the proteins that are split by this protease -- because it is critical in cellular mechanisms that underlie several major diseases.

"This communication process between cells forms the basis for the way in which certain diseases progress. This discovery will change how we understand cell behaviour and change how we consider the design of therapeutic drugs in this area" Associate Professor Lackmann said.

"This new concept in understanding of how cells communicate identifies a process that is much simpler than previously thought and which will profoundly impact the direction of future biomedical research in this area," he said.

"The research team found that instead of using complex signalling pathways, this communication system is really very direct and simple. In this case it is a transient switch in the overall shape of the contending cell surface receptor itself which activates the ADAM10 protease to communicate this change and its functional consequences to a neighbouring cell.

"The discovery of this switch opens new avenues for the development of drugs that recognise this changed shape and prevent the signalling to other cells, thus slowing or even halting the spread of disease.

The discovery was made using fluorescence and electron microscopy techniques, which allowed the observation of intact cells at single molecule resolution the changes in the shape of the cell surface receptor that occur during cell-to-cell communication.

The discovery was published online in the open-access journal PLoS Biology.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Cite This Page:

Monash University. "Milestone Discovery In Cell Behaviors." ScienceDaily. ScienceDaily, 18 October 2009. <www.sciencedaily.com/releases/2009/10/091014102205.htm>.
Monash University. (2009, October 18). Milestone Discovery In Cell Behaviors. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/10/091014102205.htm
Monash University. "Milestone Discovery In Cell Behaviors." ScienceDaily. www.sciencedaily.com/releases/2009/10/091014102205.htm (accessed September 2, 2014).

Share This




More Plants & Animals News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
Get A Mortgage, Receive A Cat — Only In Russia

Get A Mortgage, Receive A Cat — Only In Russia

Newsy (Sep. 2, 2014) — The incentive is in keeping with a Russian superstition that it's good luck for a cat to be the first to cross the threshold of a new home. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Sharks Off the Menu and on the Tourist Trail in Palau

Sharks Off the Menu and on the Tourist Trail in Palau

AFP (Sep. 2, 2014) — Tourists in Palau clamour to dive with sharks thanks to a pioneering conservation initiative -- as the island nation plans to completely ban commercial fishing in its vast ocean territory. 01:15 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins