Featured Research

from universities, journals, and other organizations

Stem Cells Restore Cognitive Abilities Impaired By Brain Tumor Treatment

Date:
November 10, 2009
Source:
University of California - Irvine
Summary:
Human embryonic stem cells could help people with learning and memory deficits after radiation treatment for brain tumors, suggests a new study.

Human embryonic stem cells could help people with learning and memory deficits after radiation treatment for brain tumors, suggests a new UC Irvine study.

Related Articles


Research with rats found that transplanted stem cells restored learning and memory to normal levels four months after radiotherapy. In contrast, irradiated rats that didn't receive stem cells experienced a more than 50 percent drop in cognitive function.

"Our findings provide the first evidence that such cells can be used to ameliorate radiation-induced damage of healthy tissue in the brain," said Charles Limoli, UCI radiation oncology associate professor and senior author of the study, appearing online the week of Nov. 9 in the Proceedings of the National Academy of Sciences.

Radiotherapy for brain tumors is limited by how well the surrounding tissue tolerates the treatment. In receiving radiation at levels needed to treat tumors, patients suffer varying degrees of learning and memory impairment that can affect their quality of life.

"It's a progressive, debilitating side effect of cranial irradiation," Limoli said. "Any treatments showing promise at reversing this are worthy of pursuit."

In the UCI study, stem cells were transplanted into the heads of rats that had undergone radiation treatment. They migrated to a brain region known to support the growth of neurons, scientists observed, and developed into new brain cells.

Work is under way to determine how the transplanted stem cells improved cognition: Did they integrate into healthy tissue or did they help repair and support existing brain cells?

Said Limoli: "With further research, stem cells may one day be used to manage a variety of adverse conditions associated with radiotherapy."

In addition to Limoli, UCI scientists Munjal Acharya, Lori-Ann Christie, Mary Lan, Peter Donovan and Carl Cotman worked on this study, in collaboration with John Fike of UC San Francisco. The UCI researchers are from the departments of radiation oncology, biological chemistry, and developmental & cell biology; the Institute for Memory Impairments and Neurological Disorders, or UCI MIND; and the Sue & Bill Gross Stem Cell Research Center.

The study was supported by grants from the California Institute for Regenerative Medicine and the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "Stem Cells Restore Cognitive Abilities Impaired By Brain Tumor Treatment." ScienceDaily. ScienceDaily, 10 November 2009. <www.sciencedaily.com/releases/2009/11/091109173600.htm>.
University of California - Irvine. (2009, November 10). Stem Cells Restore Cognitive Abilities Impaired By Brain Tumor Treatment. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/11/091109173600.htm
University of California - Irvine. "Stem Cells Restore Cognitive Abilities Impaired By Brain Tumor Treatment." ScienceDaily. www.sciencedaily.com/releases/2009/11/091109173600.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins