Featured Research

from universities, journals, and other organizations

Protection facilitates construction of molecules

Date:
November 18, 2009
Source:
NWO (Netherlands Organization for Scientific Research)
Summary:
Sulfate groups are crucial building blocks for many molecules but are difficult to handle. Chemists have now discovered how sulfate groups can be protected during the construction of a molecule. Thanks to his method new molecules, which could be used for the production of medicines, can now be constructed far more easily.

Sulfate groups are crucial building blocks for many molecules but are difficult to handle. Dutch researcher Martijn Huibers has discovered how sulfate groups can be protected during the construction of a molecule. Thanks to his method new molecules, which could be used for the production of medicines, can now be constructed far more easily.

Many sulfate groups are difficult to construct in molecules. This is partly because the products often dissolve in water and are therefore difficult to handle. Huibers solved this problem by incorporating the sulfates 'disguised' as so-called sulfite and sulfate diesters. These ensure that the sulfates remain protected during the construction process making them far easier to handle. The process is comparable to the construction of a house. During the construction you do not want to damage or break the windows and so you can protect them with wooden boards. Once the house has been completed, the boards can be removed. Just like wooden boards, the sulfite and sulfate diesters can be removed once the molecule has been constructed.

Huibers' method makes it far easier to construct organic molecules that contain sulfates. When sulfates are incorporated into molecules the yield can be very low, for example, about thirty percent; the rest is lost as a byproduct or during the purification process or it is destroyed. With Huibers' method the yield can frequently be increased to ninety percent or even more. Moreover, in theory his method makes it possible to incorporate sulfate molecules at any given moment and not only at the end of the construction process.

Drug development

Huibers is applying his new method of sulfate protection to many different molecules, including a compound that is active in the nervous system. The method has proven to be highly effective for a wide variety of constructions. With his discovery, Huibers has provided people like drug developers with a new tool.

Huibers' research was partly funded by NWO-ACTS (Advanced Chemical Technology for Sustainability). He carried out his research within the ACTS programme IBOS (Integration of Biosynthesis and Organic Synthesis) which focuses on improving the efficiency of industrial synthesis processes.


Story Source:

The above story is based on materials provided by NWO (Netherlands Organization for Scientific Research). Note: Materials may be edited for content and length.


Cite This Page:

NWO (Netherlands Organization for Scientific Research). "Protection facilitates construction of molecules." ScienceDaily. ScienceDaily, 18 November 2009. <www.sciencedaily.com/releases/2009/11/091118120312.htm>.
NWO (Netherlands Organization for Scientific Research). (2009, November 18). Protection facilitates construction of molecules. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2009/11/091118120312.htm
NWO (Netherlands Organization for Scientific Research). "Protection facilitates construction of molecules." ScienceDaily. www.sciencedaily.com/releases/2009/11/091118120312.htm (accessed August 28, 2014).

Share This




More Matter & Energy News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Australian Airlines Relax Phone Ban Too

Australian Airlines Relax Phone Ban Too

Reuters - Business Video Online (Aug. 26, 2014) Qantas and Virgin say passengers can use their smartphones and tablets throughout flights after a regulator relaxed a ban on electronic devices during take-off and landing. As Hayley Platt reports the move comes as the two domestic rivals are expected to post annual net losses later this week. Video provided by Reuters
Powered by NewsLook.com
Hurricane Marie Brings Big Waves to California Coast

Hurricane Marie Brings Big Waves to California Coast

Reuters - US Online Video (Aug. 26, 2014) Huge waves generated by Hurricane Marie hit the Southern California coast. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Chinese Researchers Might Be Creating Supersonic Submarine

Chinese Researchers Might Be Creating Supersonic Submarine

Newsy (Aug. 26, 2014) Chinese researchers have expanded on Cold War-era tech and are closer to building a submarine that could reach the speed of sound. Video provided by Newsy
Powered by NewsLook.com
Breakingviews: India Coal Strained by Supreme Court Ruling

Breakingviews: India Coal Strained by Supreme Court Ruling

Reuters - Business Video Online (Aug. 26, 2014) An acute coal shortage is likely to be aggravated as India's supreme court declared government coal allocations illegal, says Breakingviews' Peter Thal Larsen. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins