Featured Research

from universities, journals, and other organizations

Genetic Abnormality in Tumor-Associated Endothelial Cells

Date:
November 25, 2009
Source:
American Journal of Pathology
Summary:
Scientists have found that endothelial cells associated with tumors have cytogenetic abnormalities.

Dr. Kyoko Hida and colleagues at Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan and Harvard Medical School in Boston, MA have found that endothelial cells associated with tumors have cytogenetic abnormalities. They report their data in the December 2009 issue of The American Journal of Pathology.

Angiogenesis, or the growth of new blood vessels, plays a key role in tumor spread and metastasis. The endothelial cells that comprise tumor-associated blood vessels have previously been thought to be genetically stable, but recent evidence has been provided for abnormal copies of chromosomes in vascular endothelial cells in some tumor types.

Akin et al hypothesized that endothelial cells associated with human renal cell carcinoma would have cytogenetic abnormalities. They found that a portion of tumor-associated endothelial cells had aneuploidy, an abnormal number of chromosomes, and that many of these cells had stem cell-like characteristics. Abnormal endothelial cells may therefore contribute to the pathogenesis of metastatic carcinoma.

Dr. Akin and colleagues conclude that "aneuploid [tumor-assoicated endothelial cells] that organize tumor tissue surrounding the stroma might affect tumor progression and metastasis. It will be important to target abnormal tumor stroma in order to develop more effective cancer therapies."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Akino et al. Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.090202

Cite This Page:

American Journal of Pathology. "Genetic Abnormality in Tumor-Associated Endothelial Cells." ScienceDaily. ScienceDaily, 25 November 2009. <www.sciencedaily.com/releases/2009/11/091125151917.htm>.
American Journal of Pathology. (2009, November 25). Genetic Abnormality in Tumor-Associated Endothelial Cells. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/11/091125151917.htm
American Journal of Pathology. "Genetic Abnormality in Tumor-Associated Endothelial Cells." ScienceDaily. www.sciencedaily.com/releases/2009/11/091125151917.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins